A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review
Primary retroperitoneal mucinous cystic neoplasms (PRMCN) with borderline malignancy are exceptionally rare tumours with lack of pathognomonic clinical and imaging-specific features. Here, we report a case of PRMCN with borderline malignancy in a 62-year-old woman who presented with abdominal pain....
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description | Primary retroperitoneal mucinous cystic neoplasms (PRMCN) with borderline malignancy are exceptionally rare tumours with lack of pathognomonic clinical and imaging-specific features. Here, we report a case of PRMCN with borderline malignancy in a 62-year-old woman who presented with abdominal pain. Imaging studies revealed a well-defined cystic mass on the right flank in close relation with the cecum and caecal appendix, without other findings suggestive of malignancy. A possible diagnosis of an ovarian epithelial tumour was ruled out intraoperatively. After surgical excision, microscopic examination allowed the final diagnosis. As there is no evidence of disease during follow-up, complete tumour resection without cystic rupture appears to be the best therapeutic option. Thus, although rare, this tumour should be considered when imaging findings suggest an ovarian mucinous neoplasm in women with normal ovaries. An international registry for rare tumours and longer follow-ups may contribute for more consistent approach for managing these patients. |
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Here, we report a case of PRMCN with borderline malignancy in a 62-year-old woman who presented with abdominal pain. Imaging studies revealed a well-defined cystic mass on the right flank in close relation with the cecum and caecal appendix, without other findings suggestive of malignancy. A possible diagnosis of an ovarian epithelial tumour was ruled out intraoperatively. After surgical excision, microscopic examination allowed the final diagnosis. As there is no evidence of disease during follow-up, complete tumour resection without cystic rupture appears to be the best therapeutic option. Thus, although rare, this tumour should be considered when imaging findings suggest an ovarian mucinous neoplasm in women with normal ovaries. An international registry for rare tumours and longer follow-ups may contribute for more consistent approach for managing these patients.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2019-230708</identifier><identifier>PMID: 31488447</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Abdomen ; Antigens ; Biomarkers ; Carcinoma, Ovarian Epithelial - diagnosis ; Case reports ; Cystadenoma, Mucinous - diagnostic imaging ; Cystadenoma, Mucinous - pathology ; Cystadenoma, Mucinous - surgery ; Cysts ; Diagnosis, Differential ; Female ; Humans ; Laparoscopy ; Literature reviews ; Medical imaging ; Middle Aged ; Ovarian Neoplasms - diagnosis ; Pathology ; Rare Disease ; Retroperitoneal Neoplasms - diagnostic imaging ; Retroperitoneal Neoplasms - pathology ; Retroperitoneal Neoplasms - surgery ; Systematic review ; Tumors ; Urology</subject><ispartof>BMJ case reports, 2019-09, Vol.12 (9), p.e230708</ispartof><rights>BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b456t-4baec2cc9e6947df626461eea2a2d35bd3ce5e05a0dcff2e4b747197b1d4da03</citedby><cites>FETCH-LOGICAL-b456t-4baec2cc9e6947df626461eea2a2d35bd3ce5e05a0dcff2e4b747197b1d4da03</cites><orcidid>0000-0002-4842-1299 ; 0000-0003-1451-6705</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731891/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731891/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31488447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaves, Mariana M</creatorcontrib><creatorcontrib>Castro, Rita</creatorcontrib><creatorcontrib>Mota-Vieira, Luisa</creatorcontrib><creatorcontrib>Carneiro, Vítor</creatorcontrib><title>A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Primary retroperitoneal mucinous cystic neoplasms (PRMCN) with borderline malignancy are exceptionally rare tumours with lack of pathognomonic clinical and imaging-specific features. Here, we report a case of PRMCN with borderline malignancy in a 62-year-old woman who presented with abdominal pain. Imaging studies revealed a well-defined cystic mass on the right flank in close relation with the cecum and caecal appendix, without other findings suggestive of malignancy. A possible diagnosis of an ovarian epithelial tumour was ruled out intraoperatively. After surgical excision, microscopic examination allowed the final diagnosis. As there is no evidence of disease during follow-up, complete tumour resection without cystic rupture appears to be the best therapeutic option. Thus, although rare, this tumour should be considered when imaging findings suggest an ovarian mucinous neoplasm in women with normal ovaries. An international registry for rare tumours and longer follow-ups may contribute for more consistent approach for managing these patients.</description><subject>Abdomen</subject><subject>Antigens</subject><subject>Biomarkers</subject><subject>Carcinoma, Ovarian Epithelial - diagnosis</subject><subject>Case reports</subject><subject>Cystadenoma, Mucinous - diagnostic imaging</subject><subject>Cystadenoma, Mucinous - pathology</subject><subject>Cystadenoma, Mucinous - surgery</subject><subject>Cysts</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Literature reviews</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Pathology</subject><subject>Rare Disease</subject><subject>Retroperitoneal Neoplasms - diagnostic imaging</subject><subject>Retroperitoneal Neoplasms - pathology</subject><subject>Retroperitoneal Neoplasms - surgery</subject><subject>Systematic review</subject><subject>Tumors</subject><subject>Urology</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9rHCEUx6W0NCHNubci9FIK06jjjDOXQgj9BYFecuhNnvomcZnRrToJ-9_HZbch7aVefODHr773IeQtZ584b_sLY1MjGB8b0TLFhhfklKtONWpkv14-q0_Iec4bVlfL5SDb1-RkXwxSqlOyvaQJElILGWmcKNBt8gukHU1YUtxi8iUGhJkuq_UhrpnaXS7e0rIucU30wZc7amJymGYfkC4w-9sAwe4oBEdnXzBBWesTCe89PrwhryaYM54f9zNy8_XLzdX35vrntx9Xl9eNkV1fGmkArbB2xH6Uyk296GXPEUGAcG1nXGuxQ9YBc3aaBEqjpOKjMtxJB6w9I58PsdvVLOgshpJg1sfmdASv_z4J_k7fxnvdq5YPI68BH44BKf5eMRe9-GxxniFgnYIWYuhHzuQgKvr-H3RTJxNqd3tqqGq4kpW6OFA2xZwTTk-f4UzvferqU-996oPPeuPd8x6e-D_2KvDxAJhl89-0R4-orJI</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Chaves, Mariana M</creator><creator>Castro, Rita</creator><creator>Mota-Vieira, Luisa</creator><creator>Carneiro, Vítor</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4842-1299</orcidid><orcidid>https://orcid.org/0000-0003-1451-6705</orcidid></search><sort><creationdate>20190901</creationdate><title>A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review</title><author>Chaves, Mariana M ; Castro, Rita ; Mota-Vieira, Luisa ; Carneiro, Vítor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b456t-4baec2cc9e6947df626461eea2a2d35bd3ce5e05a0dcff2e4b747197b1d4da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Antigens</topic><topic>Biomarkers</topic><topic>Carcinoma, Ovarian Epithelial - diagnosis</topic><topic>Case reports</topic><topic>Cystadenoma, Mucinous - diagnostic imaging</topic><topic>Cystadenoma, Mucinous - pathology</topic><topic>Cystadenoma, Mucinous - surgery</topic><topic>Cysts</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Literature reviews</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Pathology</topic><topic>Rare Disease</topic><topic>Retroperitoneal Neoplasms - diagnostic imaging</topic><topic>Retroperitoneal Neoplasms - pathology</topic><topic>Retroperitoneal Neoplasms - surgery</topic><topic>Systematic review</topic><topic>Tumors</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaves, Mariana M</creatorcontrib><creatorcontrib>Castro, Rita</creatorcontrib><creatorcontrib>Mota-Vieira, Luisa</creatorcontrib><creatorcontrib>Carneiro, Vítor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaves, Mariana M</au><au>Castro, Rita</au><au>Mota-Vieira, Luisa</au><au>Carneiro, Vítor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>12</volume><issue>9</issue><spage>e230708</spage><pages>e230708-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>Primary retroperitoneal mucinous cystic neoplasms (PRMCN) with borderline malignancy are exceptionally rare tumours with lack of pathognomonic clinical and imaging-specific features. Here, we report a case of PRMCN with borderline malignancy in a 62-year-old woman who presented with abdominal pain. Imaging studies revealed a well-defined cystic mass on the right flank in close relation with the cecum and caecal appendix, without other findings suggestive of malignancy. A possible diagnosis of an ovarian epithelial tumour was ruled out intraoperatively. After surgical excision, microscopic examination allowed the final diagnosis. As there is no evidence of disease during follow-up, complete tumour resection without cystic rupture appears to be the best therapeutic option. Thus, although rare, this tumour should be considered when imaging findings suggest an ovarian mucinous neoplasm in women with normal ovaries. An international registry for rare tumours and longer follow-ups may contribute for more consistent approach for managing these patients.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>31488447</pmid><doi>10.1136/bcr-2019-230708</doi><orcidid>https://orcid.org/0000-0002-4842-1299</orcidid><orcidid>https://orcid.org/0000-0003-1451-6705</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Antigens Biomarkers Carcinoma, Ovarian Epithelial - diagnosis Case reports Cystadenoma, Mucinous - diagnostic imaging Cystadenoma, Mucinous - pathology Cystadenoma, Mucinous - surgery Cysts Diagnosis, Differential Female Humans Laparoscopy Literature reviews Medical imaging Middle Aged Ovarian Neoplasms - diagnosis Pathology Rare Disease Retroperitoneal Neoplasms - diagnostic imaging Retroperitoneal Neoplasms - pathology Retroperitoneal Neoplasms - surgery Systematic review Tumors Urology |
title | A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review |
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