In Vitro and In Vivo Evaluation of the Anticancer and Anti-inflammatory Activities of 2-Himachelen-7-ol isolated from Cedrus Libani

Cedrus libani is a majestic evergreen tree native to the Mediterranean mountains of Lebanon, Syria and Turkey. In this study, the tree heart wood was extracted using hexane to produce C. libani oil extract (CLOE) as a dark oil. GCMS analysis of CLOE identified up to 30 compounds whereby 2-himachalen...

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Veröffentlicht in:	Scientific reports 2019-09, Vol.9 (1), p.12855-9, Article 12855
Hauptverfasser:	Elias, Andree, Shebaby, Wassim N., Nehme, Bilal, Faour, Wissam, Bassil, Bassem S., Hakim, Joelle El, Iskandar, Rita, Dib-Jalbout, Nahia, Mroueh, Mohamad, Daher, Costantine, Taleb, Robin I.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 13/31 631/154/570 631/67/1059/99 64/60 82/16 82/58 82/6 Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Caco-2 Cells Cancer Cedrus - chemistry Cedrus libani Cell Line, Tumor Cell Survival - drug effects Cells, Cultured Cisplatin Colon Column chromatography Crystallography Cyclooxygenase-2 Cytotoxicity Edema Edema - prevention & control Hindlimb - drug effects Hindlimb - pathology HT29 Cells Humanities and Social Sciences Humans Inflammation Lipopolysaccharides Magnetic resonance spectroscopy Male Molecular Structure Monocytes multidisciplinary NMR Nuclear magnetic resonance Plant Extracts - chemistry Plant Extracts - pharmacology Rats, Sprague-Dawley Science Science (multidisciplinary) Tumor cell lines X-ray crystallography
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