circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer

Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor (HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually develop drug resistance, which remains a serious clinical challenge. To investigate roles of circular RNAs (circRNA...

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Veröffentlicht in:	Molecular therapy 2019-09, Vol.27 (9), p.1638-1652
Hauptverfasser:	Sang, Yuting, Chen, Bing, Song, Xiaojin, Li, Yaming, Liang, Yiran, Han, Dianwen, Zhang, Ning, Zhang, Hanwen, Liu, Ying, Chen, Tong, Li, Chen, Wang, Lijuan, Zhao, Wenjing, Yang, Qifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bioinformatics Biomarkers Breast cancer Cancer therapies Cell migration Cell proliferation ceRNA circRNA Drug resistance Endocrine therapy FOXO3 protein Genomes hsa_circ_0025202 Investigations Lymphatic system Menopause Metastases Metastasis MicroRNAs miRNA Mortality Original Proteins R&D Research & development Roles Tamoxifen tamoxifen resistance
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