Molecular Determinants of Ligand Selectivity in a Vertebrate Odorant Receptor

The identification of the chemical structure of an odorant by the vertebrate olfactory system is thought to occur through the combinatorial activity from multiple receptors, each tuned to recognize different chemical features. What are the molecular determinants underlying the selectivity of individ...

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Veröffentlicht in:	The Journal of neuroscience 2004-11, Vol.24 (45), p.10128-10137
Hauptverfasser:	Luu, Percy, Acher, Francine, Bertrand, Hugues-Olivier, Fan, Jinhong, Ngai, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - metabolism Animals Arginine - chemistry Arginine - metabolism Binding Sites Calcium - analysis Carassius auratus Cell Line - chemistry Cellular/Molecular Danio rerio DNA, Complementary - genetics Gene Library Glycine - chemistry Goldfish - genetics Humans Kidney - chemistry Kidney - cytology Ligands Models, Molecular Monte Carlo Method Mutagenesis, Site-Directed Protein Binding Protein Conformation Protein Structure, Tertiary Receptors, Odorant - chemistry Receptors, Odorant - genetics Receptors, Odorant - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Species Specificity Structure-Activity Relationship Substrate Specificity Zebrafish Proteins - chemistry Zebrafish Proteins - genetics
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