Neurogranin/RC3 Enhances Long-Term Potentiation and Learning by Promoting Calcium-Mediated Signaling

In neurons, neurogranin (Ng) binds calmodulin (CaM), and its binding affinity is reduced by increasing Ca2+, phosphorylation by PKC, or oxidation by oxidants. Ng concentration in the hippocampus of adult mice varied broadly (Ng+/+, 160-370 and Ng+/-, approximately 70-230 pmol/mg); the level in Ng+/+...

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Veröffentlicht in:	The Journal of neuroscience 2004-11, Vol.24 (47), p.10660-10669
Hauptverfasser:	Huang, Kuo-Ping, Huang, Freesia L, Jager, Tino, Li, Junfa, Reymann, Klaus G, Balschun, Detlef
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Behavioral/Systems/Cognitive Calcium - metabolism Calcium Signaling - physiology Calmodulin-Binding Proteins - genetics Calmodulin-Binding Proteins - metabolism Calmodulin-Binding Proteins - physiology Electric Stimulation Excitatory Postsynaptic Potentials - physiology Hippocampus - metabolism Hippocampus - physiology Learning - physiology Long-Term Potentiation - physiology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neurogranin Spatial Behavior - physiology
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