Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1 Transgenic Mice

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, polyglutamine-induced neurodegenerative disorder that results in loss of motor coordination caused primarily by a disruption of cerebellar Purkinje cell function. In this study, we developed a conditional SCA1 mouse model to examine whet...

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Veröffentlicht in:	The Journal of neuroscience 2004-10, Vol.24 (40), p.8853-8861
Hauptverfasser:	Zu, Tao, Duvick, Lisa A, Kaytor, Michael D, Berlinger, Michael S, Zoghbi, Huda Y, Clark, H. Brent, Orr, Harry T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxin-1 Ataxins Disease Models, Animal Disease Progression DNA Repeat Expansion Doxycycline - pharmacology Gene Expression Regulation Mice Mice, Transgenic Mutation Nerve Tissue Proteins - analysis Nerve Tissue Proteins - genetics Neurobiology of Disease Nuclear Proteins - analysis Nuclear Proteins - genetics Peptides - genetics Purkinje Cells - chemistry Purkinje Cells - pathology Receptors, Metabotropic Glutamate - analysis Rotarod Performance Test Spinocerebellar Ataxias - etiology Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - pathology Synapses - chemistry
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