ATP Excites Interneurons and Astrocytes to Increase Synaptic Inhibition in Neuronal Networks

We investigated the role of extracellular ATP at astrocytes and inhibitory GABAergic interneurons in the stratum radiatum area of the mouse hippocampus. We show that exogenously applied ATP increased astrocyte intracellular Ca2+ levels and depolarized all calbindinand calretinin-positive interneuron...

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Veröffentlicht in:	The Journal of neuroscience 2004-09, Vol.24 (39), p.8606-8620
Hauptverfasser:	Bowser, David N, Khakh, Baljit S
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Adenosine Triphosphate - physiology Animals Astrocytes - physiology Calbindin 2 Calbindins Calcium - physiology Cellular/Molecular Fluorescent Antibody Technique Glutamic Acid - physiology Hippocampus - cytology Hippocampus - physiology In Vitro Techniques Interneurons - physiology Mice Microscopy, Confocal Nerve Net - cytology Nerve Net - physiology Nerve Tissue Proteins - physiology Neural Inhibition - physiology Receptors, Purinergic P2 - physiology Receptors, Purinergic P2Y1 S100 Calcium Binding Protein G - physiology Synapses - physiology Thionucleotides - pharmacology
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