Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension

Protein kinase A (PKA) exerts a profound influence on axon extension during development and regeneration; however, the molecular mechanisms underlying these effects of PKA are not understood. Here, we show that DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is dis...

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Veröffentlicht in:	The Journal of neuroscience 2004-03, Vol.24 (12), p.3040-3050
Hauptverfasser:	Bouchard, Jean-Francois, Moore, Simon W, Tritsch, Nicolas X, Roux, Philippe P, Shekarabi, Masoud, Barker, Philip A, Kennedy, Timothy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclase Inhibitors Animals Axons - drug effects Axons - metabolism Axons - physiology Cell Adhesion Molecules - metabolism Cell Adhesion Molecules, Neuronal - metabolism Cell Membrane - metabolism Cells, Cultured Contactin 2 Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Development/Plasticity/Repair Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Exocytosis - drug effects Intracellular Fluid - metabolism Nerve Growth Factors - pharmacology Netrin-1 Neural Cell Adhesion Molecules - metabolism Protein Transport - drug effects Rats Rats, Sprague-Dawley Receptor, trkB - metabolism Spinal Cord - cytology Spinal Cord - embryology Spinal Cord - metabolism Tumor Suppressor Proteins - metabolism
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