Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition

The role of microglia in the removal of amyloid deposits after systemically administered anti-Abeta antibodies remains unclear. In the current study, we injected Tg2576 APP transgenic mice weekly with an anti-Abeta antibody for 1, 2, or 3 months such that all mice were 22 months at the end of the st...

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Veröffentlicht in:	The Journal of neuroscience 2004-07, Vol.24 (27), p.6144-6151
Hauptverfasser:	Wilcock, Donna M, Rojiani, Amyn, Rosenthal, Arnon, Levkowitz, Gil, Subbarao, Sangeetha, Alamed, Jennifer, Wilson, David, Wilson, Nedda, Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - immunology Amyloid - metabolism Amyloid beta-Peptides - immunology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloidosis - immunology Amyloidosis - pathology Amyloidosis - therapy Animals Antibodies, Monoclonal - pharmacology Biomarkers - metabolism Disease Models, Animal Hippocampus - metabolism Hippocampus - pathology Immunization, Passive - methods Immunoglobulin G - metabolism Immunohistochemistry Leukocyte Common Antigens - metabolism Maze Learning - drug effects Mice Mice, Transgenic Microglia - drug effects Microglia - metabolism Microglia - pathology Neurobiology of Disease Receptors, IgG - metabolism Time Factors
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