Impaired Repression at a Vasopressin Promoter Polymorphism Underlies Overexpression of Vasopressin in a Rat Model of Trait Anxiety

Two inbred rat lines have been developed that show either high (HAB) or low (LAB) anxiety-related behavior. The behavioral phenotype correlates with arginine vasopressin (AVP) expression at the level of the hypothalamic paraventricular nucleus (PVN), but not supraoptic nucleus, with HAB animals over...

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Veröffentlicht in:	The Journal of neuroscience 2004-09, Vol.24 (35), p.7762-7770
Hauptverfasser:	Murgatroyd, Chris, Wigger, Alexandra, Frank, Elisabeth, Singewald, Nicolas, Bunck, Mirjam, Holsboer, Florian, Landgraf, Rainer, Spengler, Dietmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Anxiety - genetics Arginine Vasopressin - biosynthesis Arginine Vasopressin - genetics Arginine Vasopressin - physiology Bone Neoplasms - pathology Cell Cycle Proteins Cell Line, Tumor - metabolism DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism DNA-Binding Proteins - physiology Exploratory Behavior Fear Gene Expression Regulation - genetics Heterogeneous-Nuclear Ribonucleoprotein Group A-B - physiology Humans Inbreeding Maze Learning Neurobiology of Disease Osteosarcoma - pathology Oxytocin - biosynthesis Oxytocin - genetics Paraventricular Hypothalamic Nucleus - metabolism Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Protein Binding Protein Interaction Mapping Rats Rats, Wistar Reaction Time Recombinant Fusion Proteins - biosynthesis Repressor Proteins - physiology Ribonucleoproteins Transcription Factors Transcription, Genetic Transfection
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