Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and cardiovascular development and function. Recently, a common single nucleotide polymorphism in the bdnf gene, resulting in a valine to methionine substitution in the prodomain (BDNF(Met)), has been shown to lead to m...

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Veröffentlicht in:	The Journal of neuroscience 2004-05, Vol.24 (18), p.4401-4411
Hauptverfasser:	Chen, Zhe-Yu, Patel, Paresh D, Sant, Gayatree, Meng, Chui-Xiang, Teng, Kenneth K, Hempstead, Barbara L, Lee, Francis S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cells, Cultured Cellular/Molecular Cercopithecus aethiops Cerebral Cortex - cytology Cerebral Cortex - metabolism COS Cells Dimerization Endothelial Cells - cytology Endothelial Cells - metabolism Gene Expression Humans Mice Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Mutation Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Neurons - cytology Neurons - metabolism Neurosecretory Systems - cytology Neurosecretory Systems - metabolism PC12 Cells Polymorphism, Single Nucleotide Protein Processing, Post-Translational - genetics Protein Transport - genetics Rats Transfection
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