Mice Lacking Sodium Channel β1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture

Sodium channel β1 subunits modulate α subunit gating and cell surface expression and participate in cell adhesive interactions in vitro . β1(-/-) mice appear ataxic and display spontaneous generalized seizures. In the optic nerve, the fastest components of the compound action potential are slowed an...

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Veröffentlicht in:	The Journal of neuroscience 2004-04, Vol.24 (16), p.4030-4042
Hauptverfasser:	Chen, Chunling, Westenbroek, Ruth E., Xu, Xiaorong, Edwards, Chris A., Sorenson, Dorothy R., Chen, Yuan, McEwen, Dyke P., O'Malley, Heather A., Bharucha, Vandana, Meadows, Laurence S., Knudsen, Gabriel A., Vilaythong, Alex, Noebels, Jeffrey L., Saunders, Thomas L., Scheuer, Todd, Shrager, Peter, Catterall, William A., Isom, Lori L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular/Molecular
Online-Zugang:	Volltext
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