Choline Transporter 1 Maintains Cholinergic Function in Choline Acetyltransferase Haploinsufficiency

Choline acetyltransferase (ChAT), the enzyme that synthesizes the neurotransmitter acetylcholine (ACh), is thought to be present in kinetic excess in cholinergic neurons. The rate-limiting factor in ACh production is the provision of choline to ChAT. Cholinergic neurons are relatively unique in thei...

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Veröffentlicht in:	The Journal of neuroscience 2004-06, Vol.24 (24), p.5459-5466
Hauptverfasser:	Brandon, Eugene P, Mellott, Tiffany, Pizzo, Donald P, Coufal, Nicole, D'Amour, Kevin A, Gobeske, Kevin, Lortie, Mark, Lopez-Coviella, Ignacio, Berse, Brygida, Thal, Leon J, Gage, Fred H, Blusztajn, Jan Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Behavior, Animal Behavioral/Systems/Cognitive Biological Transport Brain - metabolism Choline O-Acetyltransferase - biosynthesis Choline O-Acetyltransferase - deficiency Choline O-Acetyltransferase - genetics Hippocampus - metabolism In Vitro Techniques Membrane Transport Proteins - biosynthesis Membrane Transport Proteins - genetics Mice Mice, Mutant Strains RNA, Messenger - biosynthesis Septum of Brain - metabolism Up-Regulation
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