Histone demethylase PHF2 activates CREB and promotes memory consolidation
Long‐term memory formation is attributed to experience‐dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation‐related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is u...
Gespeichert in:
| Veröffentlicht in: | EMBO reports 2019-09, Vol.20 (9), p.e45907-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 9 |
| container_start_page | e45907 |
| container_title | EMBO reports |
| container_volume | 20 |
| creator | Kim, Hye‐Jin Hur, Sung Won Park, Jun Bum Seo, Jieun Shin, Jae Jin Kim, Seon‐Young Kim, Myoung‐Hwan Han, Do Hyun Park, Jong‐Wan Park, Joo Min Kim, Sang Jeong Chun, Yang‐Sook |
| description | Long‐term memory formation is attributed to experience‐dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation‐related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory‐related genes by epigenetically reinforcing the TrkB–CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor‐mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long‐term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases.
Synopsis
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.
The PHF2 histone demethylase is upregulated after training and facilitates memory formation.
PHF2 promotes long‐term potentiation in CA1 pyramidal neurons.
PHF2 promotes the expression of memory‐related genes by epigenetically activating TrkB–CREB signaling.
Graphical Abstract
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory. |
| doi_str_mv | 10.15252/embr.201845907 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_C6C</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6726911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2284364543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5137-5122d3ad0da54628038d63d3a32836a93e40ed27a808b2f3b2f0c86c9c7b05673</originalsourceid><addsrcrecordid>eNqFkc1LXDEUxUNRqtWuu5MHbroZzcfLx-ui0BnGjmBRRMFdyCR3NPJeMiZvLPPfN3amoxbERUi4-Z3DuRyEvhB8RDjl9Bi6aTqimKiaN1h-QLukFs2AEam21m9Kyc0O-pTzPcaYN1J9RDuMMN4ILHbR6cTnPgaoHHTQ3y1bk6G6mJzQytjeP5oecjW6HA8rE1w1T7GLT5MOupiWlY0hx9Y70_sY9tH2zLQZPq_vPXR9Mr4aTQZn5z9PRz_OBpYTJgecUOqYcdgZXguqMFNOsDJhVDFhGgY1BkelUVhN6YyVg60StrFyirmQbA99X_nOF9MOnIXQJ9PqefKdSUsdjdevf4K_07fxUQtJRUNIMfi6NkjxYQG5153PFtrWBIiLrCkVEhNBGlrQw__Q-7hIoaxXKFUzUfOaFep4RdkUc04w24QhWP-tST_VpDc1FcXByx02_L9eCvBtBfz2LSzf89PjX8PLl-54Jc5FF24hPad-K9Af7QGunQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2284364543</pqid></control><display><type>article</type><title>Histone demethylase PHF2 activates CREB and promotes memory consolidation</title><source>Springer Nature OA Free Journals</source><creator>Kim, Hye‐Jin ; Hur, Sung Won ; Park, Jun Bum ; Seo, Jieun ; Shin, Jae Jin ; Kim, Seon‐Young ; Kim, Myoung‐Hwan ; Han, Do Hyun ; Park, Jong‐Wan ; Park, Joo Min ; Kim, Sang Jeong ; Chun, Yang‐Sook</creator><creatorcontrib>Kim, Hye‐Jin ; Hur, Sung Won ; Park, Jun Bum ; Seo, Jieun ; Shin, Jae Jin ; Kim, Seon‐Young ; Kim, Myoung‐Hwan ; Han, Do Hyun ; Park, Jong‐Wan ; Park, Joo Min ; Kim, Sang Jeong ; Chun, Yang‐Sook</creatorcontrib><description>Long‐term memory formation is attributed to experience‐dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation‐related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory‐related genes by epigenetically reinforcing the TrkB–CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor‐mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long‐term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases.
Synopsis
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.
The PHF2 histone demethylase is upregulated after training and facilitates memory formation.
PHF2 promotes long‐term potentiation in CA1 pyramidal neurons.
PHF2 promotes the expression of memory‐related genes by epigenetically activating TrkB–CREB signaling.
Graphical Abstract
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.</description><identifier>ISSN: 1469-221X</identifier><identifier>ISSN: 1469-3178</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.15252/embr.201845907</identifier><identifier>PMID: 31359606</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animal memory ; Animals ; Behavioral plasticity ; Computational Biology ; Consolidation ; CREB ; Cyclic AMP response element-binding protein ; DNA methylation ; EMBO09 ; EMBO27 ; EMBO37 ; Epigenesis, Genetic - genetics ; Epigenetics ; Excitatory postsynaptic potentials ; Gene expression ; Genes ; Glutamic acid receptors (ionotropic) ; Hippocampus ; Hippocampus - metabolism ; Histone Demethylases - genetics ; Histone Demethylases - metabolism ; Histones ; Homeobox ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; learning and memory ; lysine methylation ; Male ; Mass Spectrometry ; Maze Learning ; Memory Consolidation - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular machines ; N-Methyl-D-aspartic acid receptors ; Neurons ; PHF2 ; Potentiation ; Pyramidal cells ; Signal transduction ; Signaling ; Synaptic plasticity ; TrkB receptors</subject><ispartof>EMBO reports, 2019-09, Vol.20 (9), p.e45907-n/a</ispartof><rights>The Author(s) 2019</rights><rights>2019 The Authors</rights><rights>2019 The Authors.</rights><rights>2019 EMBO</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5137-5122d3ad0da54628038d63d3a32836a93e40ed27a808b2f3b2f0c86c9c7b05673</citedby><cites>FETCH-LOGICAL-c5137-5122d3ad0da54628038d63d3a32836a93e40ed27a808b2f3b2f0c86c9c7b05673</cites><orcidid>0000-0001-8931-3713 ; 0000-0002-4283-2759 ; 0000-0002-3305-8597 ; 0000-0002-1261-9498 ; 0000-0003-3644-2516</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726911/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726911/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,41096,42165,45550,45551,46384,46808,51551,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.15252/embr.201845907$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31359606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hye‐Jin</creatorcontrib><creatorcontrib>Hur, Sung Won</creatorcontrib><creatorcontrib>Park, Jun Bum</creatorcontrib><creatorcontrib>Seo, Jieun</creatorcontrib><creatorcontrib>Shin, Jae Jin</creatorcontrib><creatorcontrib>Kim, Seon‐Young</creatorcontrib><creatorcontrib>Kim, Myoung‐Hwan</creatorcontrib><creatorcontrib>Han, Do Hyun</creatorcontrib><creatorcontrib>Park, Jong‐Wan</creatorcontrib><creatorcontrib>Park, Joo Min</creatorcontrib><creatorcontrib>Kim, Sang Jeong</creatorcontrib><creatorcontrib>Chun, Yang‐Sook</creatorcontrib><title>Histone demethylase PHF2 activates CREB and promotes memory consolidation</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO Rep</addtitle><description>Long‐term memory formation is attributed to experience‐dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation‐related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory‐related genes by epigenetically reinforcing the TrkB–CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor‐mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long‐term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases.
Synopsis
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.
The PHF2 histone demethylase is upregulated after training and facilitates memory formation.
PHF2 promotes long‐term potentiation in CA1 pyramidal neurons.
PHF2 promotes the expression of memory‐related genes by epigenetically activating TrkB–CREB signaling.
Graphical Abstract
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.</description><subject>Animal memory</subject><subject>Animals</subject><subject>Behavioral plasticity</subject><subject>Computational Biology</subject><subject>Consolidation</subject><subject>CREB</subject><subject>Cyclic AMP response element-binding protein</subject><subject>DNA methylation</subject><subject>EMBO09</subject><subject>EMBO27</subject><subject>EMBO37</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Epigenetics</subject><subject>Excitatory postsynaptic potentials</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glutamic acid receptors (ionotropic)</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Histone Demethylases - genetics</subject><subject>Histone Demethylases - metabolism</subject><subject>Histones</subject><subject>Homeobox</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>learning and memory</subject><subject>lysine methylation</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Maze Learning</subject><subject>Memory Consolidation - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Molecular machines</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Neurons</subject><subject>PHF2</subject><subject>Potentiation</subject><subject>Pyramidal cells</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Synaptic plasticity</subject><subject>TrkB receptors</subject><issn>1469-221X</issn><issn>1469-3178</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LXDEUxUNRqtWuu5MHbroZzcfLx-ui0BnGjmBRRMFdyCR3NPJeMiZvLPPfN3amoxbERUi4-Z3DuRyEvhB8RDjl9Bi6aTqimKiaN1h-QLukFs2AEam21m9Kyc0O-pTzPcaYN1J9RDuMMN4ILHbR6cTnPgaoHHTQ3y1bk6G6mJzQytjeP5oecjW6HA8rE1w1T7GLT5MOupiWlY0hx9Y70_sY9tH2zLQZPq_vPXR9Mr4aTQZn5z9PRz_OBpYTJgecUOqYcdgZXguqMFNOsDJhVDFhGgY1BkelUVhN6YyVg60StrFyirmQbA99X_nOF9MOnIXQJ9PqefKdSUsdjdevf4K_07fxUQtJRUNIMfi6NkjxYQG5153PFtrWBIiLrCkVEhNBGlrQw__Q-7hIoaxXKFUzUfOaFep4RdkUc04w24QhWP-tST_VpDc1FcXByx02_L9eCvBtBfz2LSzf89PjX8PLl-54Jc5FF24hPad-K9Af7QGunQ</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Kim, Hye‐Jin</creator><creator>Hur, Sung Won</creator><creator>Park, Jun Bum</creator><creator>Seo, Jieun</creator><creator>Shin, Jae Jin</creator><creator>Kim, Seon‐Young</creator><creator>Kim, Myoung‐Hwan</creator><creator>Han, Do Hyun</creator><creator>Park, Jong‐Wan</creator><creator>Park, Joo Min</creator><creator>Kim, Sang Jeong</creator><creator>Chun, Yang‐Sook</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8931-3713</orcidid><orcidid>https://orcid.org/0000-0002-4283-2759</orcidid><orcidid>https://orcid.org/0000-0002-3305-8597</orcidid><orcidid>https://orcid.org/0000-0002-1261-9498</orcidid><orcidid>https://orcid.org/0000-0003-3644-2516</orcidid></search><sort><creationdate>201909</creationdate><title>Histone demethylase PHF2 activates CREB and promotes memory consolidation</title><author>Kim, Hye‐Jin ; Hur, Sung Won ; Park, Jun Bum ; Seo, Jieun ; Shin, Jae Jin ; Kim, Seon‐Young ; Kim, Myoung‐Hwan ; Han, Do Hyun ; Park, Jong‐Wan ; Park, Joo Min ; Kim, Sang Jeong ; Chun, Yang‐Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5137-5122d3ad0da54628038d63d3a32836a93e40ed27a808b2f3b2f0c86c9c7b05673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal memory</topic><topic>Animals</topic><topic>Behavioral plasticity</topic><topic>Computational Biology</topic><topic>Consolidation</topic><topic>CREB</topic><topic>Cyclic AMP response element-binding protein</topic><topic>DNA methylation</topic><topic>EMBO09</topic><topic>EMBO27</topic><topic>EMBO37</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Epigenetics</topic><topic>Excitatory postsynaptic potentials</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Glutamic acid receptors (ionotropic)</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Histone Demethylases - genetics</topic><topic>Histone Demethylases - metabolism</topic><topic>Histones</topic><topic>Homeobox</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>learning and memory</topic><topic>lysine methylation</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Maze Learning</topic><topic>Memory Consolidation - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Molecular machines</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>Neurons</topic><topic>PHF2</topic><topic>Potentiation</topic><topic>Pyramidal cells</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Synaptic plasticity</topic><topic>TrkB receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hye‐Jin</creatorcontrib><creatorcontrib>Hur, Sung Won</creatorcontrib><creatorcontrib>Park, Jun Bum</creatorcontrib><creatorcontrib>Seo, Jieun</creatorcontrib><creatorcontrib>Shin, Jae Jin</creatorcontrib><creatorcontrib>Kim, Seon‐Young</creatorcontrib><creatorcontrib>Kim, Myoung‐Hwan</creatorcontrib><creatorcontrib>Han, Do Hyun</creatorcontrib><creatorcontrib>Park, Jong‐Wan</creatorcontrib><creatorcontrib>Park, Joo Min</creatorcontrib><creatorcontrib>Kim, Sang Jeong</creatorcontrib><creatorcontrib>Chun, Yang‐Sook</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kim, Hye‐Jin</au><au>Hur, Sung Won</au><au>Park, Jun Bum</au><au>Seo, Jieun</au><au>Shin, Jae Jin</au><au>Kim, Seon‐Young</au><au>Kim, Myoung‐Hwan</au><au>Han, Do Hyun</au><au>Park, Jong‐Wan</au><au>Park, Joo Min</au><au>Kim, Sang Jeong</au><au>Chun, Yang‐Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone demethylase PHF2 activates CREB and promotes memory consolidation</atitle><jtitle>EMBO reports</jtitle><stitle>EMBO Rep</stitle><addtitle>EMBO Rep</addtitle><date>2019-09</date><risdate>2019</risdate><volume>20</volume><issue>9</issue><spage>e45907</spage><epage>n/a</epage><pages>e45907-n/a</pages><issn>1469-221X</issn><issn>1469-3178</issn><eissn>1469-3178</eissn><abstract>Long‐term memory formation is attributed to experience‐dependent gene expression. Dynamic changes in histone methylation are essential for the epigenetic regulation of memory consolidation‐related genes. Here, we demonstrate that the plant homeodomain finger protein 2 (PHF2) histone demethylase is upregulated in the mouse hippocampus during the experience phase and plays an essential role in memory formation. PHF2 promotes the expression of memory‐related genes by epigenetically reinforcing the TrkB–CREB signaling pathway. In behavioral tests, memory formation is enhanced by transgenic overexpression of PHF2 in mice, but is impaired by silencing PHF2 in the hippocampus. Electrophysiological studies reveal that PHF2 elevates field excitatory postsynaptic potential (fEPSP) and NMDA receptor‐mediated evoked excitatory postsynaptic current (EPSC) in CA1 pyramidal neurons, suggesting that PHF2 promotes long‐term potentiation. This study provides insight into the epigenetic regulation of learning and memory formation, which advances our knowledge to improve memory in patients with degenerative brain diseases.
Synopsis
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.
The PHF2 histone demethylase is upregulated after training and facilitates memory formation.
PHF2 promotes long‐term potentiation in CA1 pyramidal neurons.
PHF2 promotes the expression of memory‐related genes by epigenetically activating TrkB–CREB signaling.
Graphical Abstract
Long‐term memory formation is established by experience‐dependent gene expression patterns. PHF2‐mediated epigenetic regulation of CREB serves as a molecular switch to link CREB‐dependent gene expression with activity‐dependent synaptic plasticity and memory.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31359606</pmid><doi>10.15252/embr.201845907</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0001-8931-3713</orcidid><orcidid>https://orcid.org/0000-0002-4283-2759</orcidid><orcidid>https://orcid.org/0000-0002-3305-8597</orcidid><orcidid>https://orcid.org/0000-0002-1261-9498</orcidid><orcidid>https://orcid.org/0000-0003-3644-2516</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1469-221X |
| ispartof | EMBO reports, 2019-09, Vol.20 (9), p.e45907-n/a |
| issn | 1469-221X 1469-3178 1469-3178 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6726911 |
| source | Springer Nature OA Free Journals |
| subjects | Animal memory Animals Behavioral plasticity Computational Biology Consolidation CREB Cyclic AMP response element-binding protein DNA methylation EMBO09 EMBO27 EMBO37 Epigenesis, Genetic - genetics Epigenetics Excitatory postsynaptic potentials Gene expression Genes Glutamic acid receptors (ionotropic) Hippocampus Hippocampus - metabolism Histone Demethylases - genetics Histone Demethylases - metabolism Histones Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism learning and memory lysine methylation Male Mass Spectrometry Maze Learning Memory Consolidation - physiology Mice Mice, Inbred C57BL Mice, Transgenic Molecular machines N-Methyl-D-aspartic acid receptors Neurons PHF2 Potentiation Pyramidal cells Signal transduction Signaling Synaptic plasticity TrkB receptors |
| title | Histone demethylase PHF2 activates CREB and promotes memory consolidation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T15%3A11%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_C6C&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histone%20demethylase%20PHF2%20activates%20CREB%20and%20promotes%20memory%20consolidation&rft.jtitle=EMBO%20reports&rft.au=Kim,%20Hye%E2%80%90Jin&rft.date=2019-09&rft.volume=20&rft.issue=9&rft.spage=e45907&rft.epage=n/a&rft.pages=e45907-n/a&rft.issn=1469-221X&rft.eissn=1469-3178&rft_id=info:doi/10.15252/embr.201845907&rft_dat=%3Cproquest_C6C%3E2284364543%3C/proquest_C6C%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2284364543&rft_id=info:pmid/31359606&rfr_iscdi=true |