Sex differences in the safety of S‐1 plus oxaliplatin and S‐1 plus cisplatin for patients with metastatic gastric cancer

Previous studies have shown sex‐related differences in the incidence of adverse events following treatment with fluoropyrimidines, however the mechanism of this difference is unknown. We examined sex‐related differences in the safety of S‐1 plus oxaliplatin (SOX) and S‐1 plus cisplatin (CS) in 663 m...

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Veröffentlicht in:	Cancer science 2019-09, Vol.110 (9), p.2875-2883
Hauptverfasser:	Yamada, Yasuhide, Koizumi, Wasaburo, Nishikawa, Kazuhiro, Gotoh, Masahiro, Fuse, Nozomu, Sugimoto, Naotoshi, Nishina, Tomohiro, Amagai, Kenji, Chin, Keisho, Niwa, Yasumasa, Tsuji, Akihito, Imamura, Hiroshi, Tsuda, Masahiro, Yasui, Hirofumi, Fujii, Hirofumi, Yamaguchi, Kensei, Yasui, Hisateru, Hironaka, Shuichi, Shimada, Ken, Hyodo, Ichinosuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Body mass index Cancer therapies Chemotherapy Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Diarrhea Disease-Free Survival Dose-Response Relationship, Drug Drug Combinations Enzymes Female fluorouracil Gastric cancer Gender differences Humans Incidence Leukopenia Male Medical prognosis Metastases Metastasis Middle Aged Nausea Nausea - chemically induced Nausea - epidemiology Neutropenia Neutropenia - chemically induced Neutropenia - epidemiology Original Oxaliplatin Oxaliplatin - administration & dosage Oxaliplatin - adverse effects Oxonic Acid - administration & dosage Oxonic Acid - adverse effects Pharmaceuticals Potassium Research funding sex Sex differences Sex Factors Stomach Neoplasms - blood Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Stomatitis Stomatitis - chemically induced Stomatitis - epidemiology Studies S‐1 Tegafur - administration & dosage Tegafur - adverse effects Thrombocytopenia Thrombocytopenia - chemically induced Thrombocytopenia - epidemiology Vomiting Vomiting - chemically induced Vomiting - epidemiology
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Zusammenfassung:	Previous studies have shown sex‐related differences in the incidence of adverse events following treatment with fluoropyrimidines, however the mechanism of this difference is unknown. We examined sex‐related differences in the safety of S‐1 plus oxaliplatin (SOX) and S‐1 plus cisplatin (CS) in 663 metastatic gastric cancer patients taking part in a phase III study. The incidences of leukopenia (odds ratio [OR] 1.9; P = .015), neutropenia (OR 2.2; P = .002), nausea (OR 2.0; P = .009), and vomiting (OR 2.8; P
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.14117