Trafficking mechanisms of P-type ATPase copper transporters

Copper is an essential micronutrient required for oxygen-dependent enzymes, yet excess of the metal is a toxicant. The tug-of-war between these copper activities is balanced by chaperones and membrane transporters, which control copper distribution and availability. The P-type ATPase transporters, A...

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Veröffentlicht in:	Current opinion in cell biology 2019-08, Vol.59, p.24-33
Hauptverfasser:	Hartwig, Cortnie, Zlatic, Stephanie A, Wallin, Melissa, Vrailas-Mortimer, Alysia, Fahrni, Christoph J, Faundez, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Copper Transport Proteins - metabolism Copper-Transporting ATPases - metabolism Humans Mitochondria - metabolism Mutation - genetics Parkinson Disease - genetics Protein Transport
Online-Zugang:	Volltext
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