Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here, we show that EZH2 and NRAS mutations cooperatively induce progression of myeloproliferative neoplasms to highly penet...

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Veröffentlicht in:	Cancer discovery 2019-09, Vol.9 (9), p.1228-1247
Hauptverfasser:	Gu, Zhimin, Liu, Yuxuan, Cai, Feng, Patrick, McKenzie, Zmajkovic, Jakub, Cao, Hui, Zhang, Yuannyu, Tasdogan, Alpaslan, Chen, Mingyi, Qi, Le, Liu, Xin, Li, Kailong, Lyu, Junhua, Dickerson, Kathryn E, Chen, Weina, Ni, Min, Merritt, Matthew E, Morrison, Sean J, Skoda, Radek C, DeBerardinis, Ralph J, Xu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Branched-Chain - metabolism Animals Enhancer of Zeste Homolog 2 Protein - genetics Enhancer of Zeste Homolog 2 Protein - metabolism GTP Phosphohydrolases - genetics Humans Leukemia - genetics Leukemia - metabolism Leukemia - pathology Membrane Proteins - genetics Mice Mutation Myeloproliferative Disorders - complications Myeloproliferative Disorders - genetics Myeloproliferative Disorders - metabolism Neoplasm Transplantation Signal Transduction TOR Serine-Threonine Kinases - metabolism Transaminases - metabolism
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