Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin

Betaglycan (BG) and endoglin (ENG), homologous co-receptors of the TGF-β family, potentiate the signaling activity of TGF-β2 and inhibin A, and BMP-9 and BMP-10, respectively. BG exists as monomer and forms 1:1 growth factor (GF) complexes, while ENG exists as a dimer and forms 2:1 GF complexes. Her...

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Veröffentlicht in:Structure (London) 2019-09, Vol.27 (9), p.1427-1442.e4
Hauptverfasser: Kim, Sun Kyung, Whitley, Matthew J., Krzysiak, Troy C., Hinck, Cynthia S., Taylor, Alexander B., Zwieb, Christian, Byeon, Chang-Hyeock, Zhou, Xiaohong, Mendoza, Valentín, López-Casillas, Fernando, Furey, William, Hinck, Andrew P.
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Sprache:eng
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