Neurosteroid-Induced Plasticity of Immature Synapses via Retrograde Modulation of Presynaptic NMDA Receptors

Neurosteroids are produced de novo in neuronal and glial cells, which begin to express steroidogenic enzymes early in development. Studies suggest that neurosteroids may play important roles in neuronal circuit maturation via autocrine and/or paracrine actions. However, the mechanism of action of th...

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Veröffentlicht in:	The Journal of neuroscience 2005-03, Vol.25 (9), p.2285-2294
Hauptverfasser:	Mameli, Manuel, Carta, Mario, Partridge, L. Donald, Valenzuela, C. Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Antibodies - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Chelating Agents - pharmacology Development/Plasticity/Repair Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Interactions Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electric Stimulation Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects Hippocampus - cytology In Vitro Techniques Life Sciences Membrane Potentials - drug effects Membrane Potentials - physiology Membrane Potentials - radiation effects Neuronal Plasticity - drug effects Patch-Clamp Techniques - methods Piperidines - pharmacology Pregnenolone - immunology Pregnenolone - pharmacology Presynaptic Terminals - physiology Quinolinic Acids - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Sodium Channel Blockers - pharmacology Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Tetrodotoxin - pharmacology Time Factors
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