Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited

The sequential enzymatic actions of beta-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the gamma-secretase complex liberate beta-amyloid (Abeta) peptides from larger integral membrane proteins, termed beta-amyloid precursor proteins (APPs). Relatively little is known about t...

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Veröffentlicht in:	The Journal of neuroscience 2005-03, Vol.25 (9), p.2386-2395
Hauptverfasser:	Lazarov, Orly, Morfini, Gerardo A, Lee, Edward B, Farah, Mohamed H, Szodorai, Anita, DeBoer, Scott R, Koliatsos, Vassilis E, Kins, Stefan, Lee, Virginia M.-Y, Wong, Philip C, Price, Donald L, Brady, Scott T, Sisodia, Sangram S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - deficiency Amyloid beta-Protein Precursor - physiology Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Axons - physiology Blotting, Western - methods Brain - cytology Brain - metabolism Cloning, Molecular - methods Endopeptidases - deficiency Gene Expression - physiology Glutathione Transferase - physiology Green Fluorescent Proteins - biosynthesis Humans Immunohistochemistry Immunoprecipitation - methods Kinesin - genetics Kinesin - physiology Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Neurobiology of Disease Presenilin-1 Protein Binding Protein Biosynthesis - physiology Protein Transport - physiology Receptor Protein-Tyrosine Kinases - metabolism Recombinant Fusion Proteins - metabolism Sciatic Nerve - cytology Sciatic Neuropathy - metabolism
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