Quantitative 1H Magnetic Resonance Spectroscopic Imaging Determines Therapeutic Immunization Efficacy in an Animal Model of Parkinson's Disease

Nigrostriatal degeneration, the pathological hallmark of Parkinson's disease (PD), is mirrored by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. MPTP-treated animals show the common behavioral, motor, and pathological features of human disease. We demonstrated previously that...

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Veröffentlicht in:	The Journal of neuroscience 2005-02, Vol.25 (7), p.1691-1700
Hauptverfasser:	Boska, Michael D, Lewis, Travis B, Destache, Christopher J, Benner, Eric J, Nelson, Jay A, Uberti, Mariano, Mosley, R. Lee, Gendelman, Howard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Aspartic Acid - analogs & derivatives Aspartic Acid - analysis Cell Count Chromatography, High Pressure Liquid Corpus Striatum - chemistry Corpus Striatum - immunology Corpus Striatum - pathology Dopamine - physiology Glatiramer Acetate Immunization Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Mice Microglia - physiology MPTP Poisoning - metabolism MPTP Poisoning - pathology MPTP Poisoning - therapy Myelin Basic Protein - immunology Nerve Degeneration - immunology Nerve Tissue Proteins - analysis Neurobiology of Disease Ovalbumin - immunology Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Parkinsonian Disorders - therapy Peptides - immunology Substantia Nigra - chemistry Substantia Nigra - immunology Substantia Nigra - pathology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation Tyrosine 3-Monooxygenase - analysis
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