Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity

A deficit in inhibition in the spinal dorsal horn has been proposed to be an underlying cause of the exaggerated cutaneous sensory reflexes observed in newborn rats. However, the developmental shift in transmembrane anion gradient, potentially affecting the outcome of GABAA transmission, was shown t...

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Veröffentlicht in:	The Journal of neuroscience 2005-10, Vol.25 (42), p.9613-9623
Hauptverfasser:	Cordero-Erausquin, Matilde, Coull, Jeffrey A. M, Boudreau, Dominic, Rolland, Matthias, Koninck, Yves De
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Anions Calcium Channels - physiology Calcium Signaling - drug effects Calcium Signaling - physiology Cellular/Molecular Chloride Channels - physiology GABA-A Receptor Agonists gamma-Aminobutyric Acid - pharmacology Posterior Horn Cells - drug effects Posterior Horn Cells - growth & development Posterior Horn Cells - physiology Rats Rats, Sprague-Dawley Receptors, GABA-A - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology
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