Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death

Cyclin-dependent kinase 5 (cdk5) is a member of the cyclin-dependent kinase family whose activity is localized mainly to postmitotic neurons attributable to the selective expression of its activating partners p35 and p39. Deregulation of cdk5, as a result of calpain cleavage of p35 to a smaller p25...

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Veröffentlicht in:	The Journal of neuroscience 2005-09, Vol.25 (39), p.8954-8966
Hauptverfasser:	O'Hare, Michael J, Kushwaha, Neena, Zhang, Yi, Aleyasin, Hossein, Callaghan, Steven M, Slack, Ruth S, Albert, Paul R, Vincent, Inez, Park, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Caspases - metabolism Cell Death - physiology Cell Line Cell Nucleus - metabolism Cyclin-Dependent Kinase 5 - physiology Cytoplasm - metabolism DNA Damage - physiology Enzyme Activation Glutamic Acid - pharmacology Humans Mice Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - biosynthesis Neurobiology of Disease Neurons - drug effects Neurons - physiology Neurotoxins - pharmacology Phosphotransferases
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