Differential Vesicular Targeting and Time Course of Synaptic Secretion of the Mammalian Neurotrophins

Neurotrophins are a family of secreted neuronal survival and plasticity factors comprising NGF, BDNF, neurotrophin-3 (NT-3), and NT-4. Whereas synaptic secretion of BDNF has been described, the routes of intracellular targeting and secretion of NGF, NT-3, and NT-4 in neurons are poorly understood. T...

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Veröffentlicht in:	The Journal of neuroscience 2005-08, Vol.25 (33), p.7601-7614
Hauptverfasser:	Brigadski, Tanja, Hartmann, Matthias, Lessmann, Volkmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cercopithecus aethiops COS Cells Development/Plasticity/Repair Hippocampus - metabolism Humans Nerve Growth Factors - metabolism PC12 Cells Rats Synapses - metabolism Synaptic Vesicles - metabolism Time Factors
Online-Zugang:	Volltext
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