Synaptic Targeting of Retrogradely Transported Trophic Factors in Motoneurons: Comparison of Glial Cell Line-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor, and Cardiotrophin-1 with Tetanus Toxin

Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and cardiotrophin-1 (CT-1) are the most potent neurotrophic factors for motoneurons, but their fate after retrograde axonal transport is not known. Internalized trophic factors may be degraded, or they may...

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Veröffentlicht in:	The Journal of neuroscience 2005-01, Vol.25 (3), p.539-549
Hauptverfasser:	Rind, Howard B, Butowt, Rafal, von Bartheld, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Axonal Transport - physiology Brain Stem - metabolism Brain-Derived Neurotrophic Factor - metabolism Cytokines - metabolism Cytoplasmic Vesicles - metabolism Dendrites - metabolism Development/Plasticity/Repair Glial Cell Line-Derived Neurotrophic Factor Growth Substances - metabolism Hypoglossal Nerve - cytology Iodine Radioisotopes Motor Neurons - metabolism Motor Neurons - ultrastructure Nerve Growth Factors - metabolism Protein Transport Rats Rats, Wistar Synapses - metabolism Tetanus Toxin - metabolism
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