Protons trap NR1/NR2B NMDA receptors in a nonconducting state

NMDA receptors are highly expressed in the CNS and are involved in excitatory synaptic transmission, as well as synaptic plasticity. Given that overstimulation of NMDA receptors can cause cell death, it is not surprising that these channels are under tight control by a series of inhibitory extracell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2005-01, Vol.25 (1), p.42-51
Hauptverfasser:	Banke, Tue G, Dravid, Shashank M, Traynelis, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Line Cellular/Molecular Glutamic Acid - metabolism Glutamic Acid - pharmacology Glycine - metabolism Humans Hydrogen-Ion Concentration Ion Channel Gating - physiology Kinetics Models, Chemical Protein Conformation Protons Rats Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Receptors, N-Methyl-D-Aspartate - physiology Recombinant Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!