Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death

Expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the Wnt pathway, was induced in the hippocampus of gerbils and rats subjected to transient global cerebral ischemia as well as in cultured cortical neurons challenged with an excitotoxic pulse. In ischemic animals, the te...

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Veröffentlicht in:The Journal of neuroscience 2005-03, Vol.25 (10), p.2647-2657
Hauptverfasser: Cappuccio, Irene, Calderone, Agata, Busceti, Carla L, Biagioni, Francesca, Pontarelli, Fabrizio, Bruno, Valeria, Storto, Marianna, Terstappen, Georg T, Gaviraghi, Giovanni, Fornai, Francesco, Battaglia, Giuseppe, Melchiorri, Daniela, Zukin, Suzanne, Nicoletti, Ferdinando, Caricasole, Andrea
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Sprache:eng
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