AMPA/Kainate Receptor-Mediated Downregulation of GABAergic Synaptic Transmission by Calcineurin after Seizures in the Developing Rat Brain

Hypoxia is the most common cause of perinatal seizures and can be refractory to conventional anticonvulsant drugs, suggesting an age-specific form of epileptogenesis. A model of hypoxia-induced seizures in immature rats reveals that seizures result in immediate activation of the phosphatase calcineu...

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Veröffentlicht in:	The Journal of neuroscience 2005-03, Vol.25 (13), p.3442-3451
Hauptverfasser:	Sanchez, Russell M, Dai, Weimin, Levada, Rachel E, Lippman, Jocelyn J, Jensen, Frances E
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Animals Animals, Newborn Blotting, Western - methods Calcineurin - physiology Development/Plasticity/Repair Dose-Response Relationship, Radiation Electric Stimulation - methods Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects gamma-Aminobutyric Acid - metabolism Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Hippocampus - growth & development Hippocampus - pathology Hippocampus - physiopathology Hypoxia - complications Immunoprecipitation - methods In Vitro Techniques Neural Inhibition - drug effects Neural Inhibition - physiology Neural Inhibition - radiation effects Patch-Clamp Techniques - methods Rats Receptors, AMPA - physiology Receptors, GABA-A - metabolism Seizures - etiology Seizures - metabolism Seizures - physiopathology Synapses - metabolism Synaptic Transmission - physiology Tacrolimus - pharmacology Time Factors
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