Regulation of NMDA Receptors by Neuregulin Signaling in Prefrontal Cortex

Recent linkage studies have identified a significant association of the neuregulin gene with schizophrenia, but how neuregulin is involved in schizophrenia is primarily unknown. Aberrant NMDA receptor functions have been implicated in the pathophysiology of schizophrenia. Therefore, we hypothesize t...

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Veröffentlicht in:	The Journal of neuroscience 2005-05, Vol.25 (20), p.4974-4984
Hauptverfasser:	Gu, Zhenglin, Jiang, Qian, Fu, Amy K. Y, Ip, Nancy Y, Yan, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Boron Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cells, Cultured Cellular/Molecular Chelating Agents - pharmacology Cytochalasin D - pharmacology Dose-Response Relationship, Drug Drug Interactions Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electric Stimulation - methods Enzyme Inhibitors - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects Membrane Potentials - drug effects Membrane Potentials - radiation effects N-Methylaspartate - pharmacology Neural Inhibition - drug effects Neural Inhibition - physiology Neural Inhibition - radiation effects Neuregulin-1 - metabolism Neuregulin-1 - pharmacology Neurons - drug effects Neurons - physiology Nucleic Acid Synthesis Inhibitors - pharmacology Patch-Clamp Techniques - methods Prefrontal Cortex - cytology Pyrimidines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Signal Transduction - drug effects Signal Transduction - physiology Thiazoles - pharmacology Thiazolidines
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