Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones
Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women than men. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these disorders. Evidence suggests that PACAP has a critical role in the...
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| Veröffentlicht in: | Stress (Amsterdam, Netherlands) Netherlands), 2017-09, Vol.20 (5), p.465-475 |
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| creator | King, S. Bradley Toufexis, Donna J. Hammack, Sayamwong E. |
| description | Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women than men. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these disorders. Evidence suggests that PACAP has a critical role in the stress circuits mediating stress-responding, and PACAP may interact with sex hormones to contribute to sex differences in stress-related disease. In this review, we describe the role of the PACAP/PAC1 system in stress biology, focusing on the role of stress-induced alterations in PACAP expression and signaling in the development of stress-induced behavioral change. Additionally, we present more recent data suggesting potential interactions between stress, PACAP, and circulating estradiol in pathological states, including PTSD. These studies suggest that the level of stress and circulating gonadal hormones may differentially regulate the PACAPergic system in males and females to influence anxiety-like behavior and may be one mechanism underlying the discrepancies in human psychiatric disorders. |
| doi_str_mv | 10.1080/10253890.2017.1336535 |
| format | Article |
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Additionally, we present more recent data suggesting potential interactions between stress, PACAP, and circulating estradiol in pathological states, including PTSD. 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Bradley</creatorcontrib><creatorcontrib>Toufexis, Donna J.</creatorcontrib><creatorcontrib>Hammack, Sayamwong E.</creatorcontrib><title>Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones</title><title>Stress (Amsterdam, Netherlands)</title><addtitle>Stress</addtitle><description>Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women than men. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these disorders. Evidence suggests that PACAP has a critical role in the stress circuits mediating stress-responding, and PACAP may interact with sex hormones to contribute to sex differences in stress-related disease. In this review, we describe the role of the PACAP/PAC1 system in stress biology, focusing on the role of stress-induced alterations in PACAP expression and signaling in the development of stress-induced behavioral change. Additionally, we present more recent data suggesting potential interactions between stress, PACAP, and circulating estradiol in pathological states, including PTSD. 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Bradley ; Toufexis, Donna J. ; Hammack, Sayamwong E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-7ffb1b7cb4a37c05409229b6f0d3d93919f817812c9db0c0eb1416b31d8039d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>anxiety</topic><topic>Anxiety - metabolism</topic><topic>bed nucleus of the stria terminalis</topic><topic>Estradiol - metabolism</topic><topic>Estrogen</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>PAC1</topic><topic>Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism</topic><topic>PTSD</topic><topic>Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism</topic><topic>Septal Nuclei - metabolism</topic><topic>Sex Characteristics</topic><topic>sex difference</topic><topic>Sex Factors</topic><topic>Stress Disorders, Post-Traumatic - metabolism</topic><topic>Stress, Psychological - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, S. Bradley</creatorcontrib><creatorcontrib>Toufexis, Donna J.</creatorcontrib><creatorcontrib>Hammack, Sayamwong E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stress (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, S. 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| ispartof | Stress (Amsterdam, Netherlands), 2017-09, Vol.20 (5), p.465-475 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals anxiety Anxiety - metabolism bed nucleus of the stria terminalis Estradiol - metabolism Estrogen Female Gonadal Steroid Hormones - metabolism Humans Male Mice PAC1 Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism PTSD Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism Septal Nuclei - metabolism Sex Characteristics sex difference Sex Factors Stress Disorders, Post-Traumatic - metabolism Stress, Psychological - metabolism |
| title | Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones |
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