Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis

Background & AimsThe exocrine pancreas consists of acinar cells that produce digestive enzymes transported to the intestine through a branched ductal epithelium. Chronic pancreatitis is characterized by progressive inflammation, fibrosis, and loss of acinar tissue. These changes of the exocrine...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2019-01, Vol.8 (3), p.487-511
Hauptverfasser:	Quilichini, Evans, Fabre, Mélanie, Dirami, Thassadite, Stedman, Aline, De Vas, Matias, Ozguc, Ozge, Pasek, Raymond C, Cereghini, Silvia, Morillon, Lucie, Guerra, Carmen, Couvelard, Anne, Gannon, Maureen, Haumaitre, Cécile
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar-to-Ductal-Metaplasia Animals Animals, Newborn Cancer Carcinoma in Situ - genetics Carcinoma in Situ - metabolism Ducts Female Gastroenterology and Hepatology Gene Deletion Genetic Predisposition to Disease Hepatocyte Nuclear Factor 1-beta - genetics Hepatocyte Nuclear Factor 1-beta - metabolism Hnf1b Homeostasis Human health and pathology Humans Hépatology and Gastroenterology Life Sciences Mice Original Research Pancreas, Exocrine - metabolism Pancreatic Cancer Pancreatic Ducts - growth & development Pancreatic Ducts - metabolism Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatitis Pancreatitis - complications Pancreatitis - genetics Pancreatitis - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!