MHC‐restricted Ag85B‐specific CD8+ T cells are enhanced by recombinant BCG prime and DNA boost immunization in mice

Despite efforts to develop effective treatments and vaccines, Mycobacterium tuberculosis (Mtb), particularly pulmonary Mtb, continues to provide major health challenges worldwide. To improve immunization against the persistent health challenge of Mtb infection, we have studied the CD8+ T cell respon...

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Veröffentlicht in:	European journal of immunology 2019-09, Vol.49 (9), p.1399-1414
Hauptverfasser:	Komine‐Aizawa, Shihoko, Jiang, Jiansheng, Mizuno, Satoru, Hayakawa, Satoshi, Matsuo, Kazuhiro, Boyd, Lisa F., Margulies, David H., Honda, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - immunology Ag85B protein Amino Acid Sequence Animals Antigens, Bacterial - immunology Bacillus Calmette-Guerin vaccine Bacterial Proteins - immunology BCG BCG Vaccine - immunology CD4+ T Cells CD8 antigen CD8+ T Cells CD8-Positive T-Lymphocytes - immunology Deoxyribonucleic acid DNA Epitopes Epitopes - immunology Female Histocompatibility Antigens Class I - metabolism Immunization Immunization - methods Immunization, Secondary - methods Lymphocytes Lymphocytes T Major histocompatibility complex MHC‐I presentation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium bovis - immunology Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis, recombinant BCG Peptides Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Vaccination - methods Vaccines Vaccines, DNA - immunology
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