Activity and characterization of a pH-sensitive antimicrobial peptide

Antimicrobial peptides (AMPs) have been an area of great interest, due to the high selectivity of these molecules toward bacterial targets over host cells and the limited development of bacterial resistance to these molecules throughout evolution. Previous work showed that when Histidine was incorpo...

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Veröffentlicht in:	Biochimica et biophysica acta. Biomembranes 2019-10, Vol.1861 (10), p.182984-182984, Article 182984
Hauptverfasser:	Hitchner, Morgan A., Santiago-Ortiz, Luis E., Necelis, Matthew R., Shirley, David J., Palmer, Thaddeus J., Tarnawsky, Katharine E., Vaden, Timothy D., Caputo, Gregory A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - metabolism Anti-Infective Agents - chemistry Anti-Infective Agents - metabolism Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - therapeutic use Antimicrobial peptides Cell Membrane - chemistry Cell Membrane Permeability - drug effects Fluorescence Histidine Hydrogen-Ion Concentration Lipid Bilayers - chemistry Lipid binding Membrane permeabilization Peptides - chemistry Peptides - therapeutic use pH-dependence Phosphatidylcholines - chemistry Phosphatidylglycerols - chemistry Structure-Activity Relationship
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