The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?

The hedgehog (Hh) pathway plays a key role in embryonic development and stem cell programs. Deregulation of the Hh pathway is a key driver of basal cell carcinoma, and therapeutic targeting led to approval of Hh inhibitor, vismodegib, in the management of this cancer. The Hh pathway is implicated in...

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Veröffentlicht in:	Cancers 2019-08, Vol.11 (8), p.1126
Hauptverfasser:	Bhateja, Priyanka, Cherian, Mathew, Majumder, Sarmila, Ramaswamy, Bhuvaneswari
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Basal cell carcinoma Breast cancer Breastfeeding & lactation Cancer therapies Cell activation Cell cycle Cell proliferation Chemoresistance Chemotherapy Clinical trials Drug development Drug resistance Embryogenesis Endocrine therapy Estrogens Gene expression Glioma Hedgehog protein Kinases Ligands Mesenchyme Metastasis Paracrine signalling Proteins Review Signal transduction Stem cells Tamoxifen Therapeutic targets Transcription factors Tumors Wnt protein
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