Chlorin e6-Loaded PEG-PCL Nanoemulsion for Photodynamic Therapy and In Vivo Drug Delivery

We fabricated poly (ethylene glycol)-block-polycaprolactone (PEG-b-PCL) nanoemulsion for drug delivery and photodynamic therapy. PEG-b-PCL effectively stabilized the interface between water and soybean oil, and the resulting nanoemulsion was about 220.3 nm in diameter with spherical shape. For photo...

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Veröffentlicht in:	International journal of molecular sciences 2019-08, Vol.20 (16), p.3958
Hauptverfasser:	Park, Changhee, Yoo, Jihye, Lee, Donghyun, Jang, Seok-Young, Kwon, Soonmin, Koo, Heebeom
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Breast cancer Cell Survival - drug effects Cell viability Cells, Cultured Cytotoxicity Dose-Response Relationship, Drug Drug Carriers - chemistry Drug delivery Drug Delivery Systems Emulsions - chemistry Glycolic acid Hydrophobicity In vivo methods and tests Intravenous administration Lactones - chemistry Lasers Lecithin Ligands Melting points Metastasis Mice Models, Animal Nanoemulsions Nanoparticles - chemistry Nanoparticles - ultrastructure Oil Photochemotherapy Photodynamic therapy Polyethylene Glycols - chemistry Polylactic acid Polylactide-co-glycolide Polymers Porphyrins - administration & dosage Porphyrins - chemistry Porphyrins - pharmacokinetics Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - chemistry Sodium deoxycholate Sodium dodecyl sulfate Sorbitan Soybeans Surface tension Surfactants Tissue Distribution Toxicity testing Tumors Vegetable oils
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