The Antitumor Activity of TCR-Mimic Antibody-Drug Conjugates (TCRm-ADCs) Targeting the Intracellular Wilms Tumor 1 (WT1) Oncoprotein

Wilms tumor 1 (WT1) oncoprotein is an intracellular oncogenic transcription factor which is barely expressed in normal adult tissues but over expressed in a variety of leukemias and solid cancers. WT1-derived HLA-A*02:01 T cell epitope, RMFPNAPYL (RMF), is a validated target for T cell-based immunot...

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Veröffentlicht in:	International journal of molecular sciences 2019-08, Vol.20 (16), p.3912
Hauptverfasser:	Shen, Ying, Li, Yi-Ming, Zhou, Jing-Jing, Zhou, Zhan, Xu, Ying-Chun, Zhao, Wen-Bin, Chen, Shu-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antineoplastic Agents, Immunological - therapeutic use Antitumor activity Bispecific antibodies Cancer Cell Line, Tumor Chimeric antigen receptors Chromatography Cytotoxicity Epitopes Flow cytometry Glycosylation Histocompatibility antigen HLA HLA-A Antigens - immunology Humans Immunoconjugates - therapeutic use Immunoglobulins Internalization Kidney Neoplasms - drug therapy Kidney Neoplasms - immunology Leukemia Male Medical research Mice, Inbred BALB C Mice, Nude Oncoproteins Peptides Proteins Receptors, Antigen, T-Cell - immunology T cell receptors Tumors Wilms Tumor - drug therapy Wilms Tumor - immunology WT1 protein WT1 Proteins - immunology
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