Left Ventricular Hypertrophy: Roles of Mitochondria CYP1B1 and Melatonergic Pathways in Co-Ordinating Wider Pathophysiology

Left ventricular hypertrophy (LVH) can be adaptive, as arising from exercise, or pathological, most commonly when driven by hypertension. The pathophysiology of LVH is consistently associated with an increase in cytochrome P450 (CYP)1B1 and mitogen-activated protein kinases (MAPKs) and a decrease in...

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Veröffentlicht in:	International journal of molecular sciences 2019-08, Vol.20 (16), p.4068
Hauptverfasser:	Anderson, George, Mazzoccoli, Gianluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Blood pressure Brain-derived neurotrophic factor Cardiomyocytes Cyclic AMP response element-binding protein Cytochrome P-450 CYP1B1 - genetics Cytochrome P-450 CYP1B1 - metabolism Cytokines Deoxyribonucleic acid Diabetes Digestive system DNA Fibrosis Gastrointestinal Microbiome - physiology Gene expression Humans Hydrocarbons Hypertension Hypertrophy Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - physiopathology Inflammation Kinases Ligands MAP kinase Melatonin Melatonin - metabolism Metabolites Microbiota Mitochondria Mitochondria - metabolism Mitogen-Activated Protein Kinases - metabolism Oxidative stress Physiology Protein kinase Proteins Renal function Review Roles Sirtuins - metabolism Transcription Ventricle
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