Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

Histone acetyltransferase 1 (Hat1) is responsible for the acetylation of newly synthesized histone H4 on lysines 5 and 12 during the process of chromatin assembly. To understand the broader biological role of Hat1, we have generated a conditional mouse knockout model of this enzyme. We previously re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aging cell 2019-10, Vol.18 (5), p.e12992-n/a
Hauptverfasser:	Nagarajan, Prabakaran, Agudelo Garcia, Paula A., Iyer, Chitra C., Popova, Liudmila V., Arnold, William D., Parthun, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Acetylation Aging Aging - metabolism Animals Atrophy Chromatin remodeling Defects DNA damage Embryo fibroblasts Epigenetic inheritance Fibroblasts Genomes Growth rate Haploinsufficiency Hat1 histone Histone acetyltransferase Histone Acetyltransferases - deficiency Histone Acetyltransferases - metabolism Histone H4 Histones Life span Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - enzymology Mitochondria - pathology mRNA Original Paper Paralysis Phenotypes Reactive oxygen species Senescence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!