Therapeutic implications of nanomedicine for ocular drug delivery
•Ocular nanomedicine with great clinical translational potential.•Nanomedicine can be used for treating anterior and posterior eye diseases.•The principles of nanomedicine for targeted and sustained ocular drug delivery.•The perspectives of ocular nanomedicine include scale-up manufacturing and safe...
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| Veröffentlicht in: | Drug discovery today 2019-08, Vol.24 (8), p.1524-1538 |
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| container_title | Drug discovery today |
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| creator | Meng, Tuo Kulkarni, Vineet Simmers, Russell Brar, Vikram Xu, Qingguo |
| description | •Ocular nanomedicine with great clinical translational potential.•Nanomedicine can be used for treating anterior and posterior eye diseases.•The principles of nanomedicine for targeted and sustained ocular drug delivery.•The perspectives of ocular nanomedicine include scale-up manufacturing and safety profiles.
Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood–retinal barrier when drugs are administered systemically, and the cornea when drugs are administered topically, is difficult to achieve; limited drug penetration to the back of the eye owing to the cornea, conjunctiva, sclera and vitreous barriers. Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity. In this review, we highlight the therapeutic implications of nanomedicine for ocular drug delivery.
Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine can overcome ocular barriers, improve drug-release profiles and reduce potential drug toxicity. |
| doi_str_mv | 10.1016/j.drudis.2019.05.006 |
| format | Article |
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Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood–retinal barrier when drugs are administered systemically, and the cornea when drugs are administered topically, is difficult to achieve; limited drug penetration to the back of the eye owing to the cornea, conjunctiva, sclera and vitreous barriers. Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity. In this review, we highlight the therapeutic implications of nanomedicine for ocular drug delivery.
Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine can overcome ocular barriers, improve drug-release profiles and reduce potential drug toxicity.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2019.05.006</identifier><identifier>PMID: 31102733</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Drug Carriers - chemistry ; Drug Delivery Systems - methods ; Eye - drug effects ; Humans ; Nanomedicine - methods ; Ophthalmic Solutions - administration & dosage ; Ophthalmic Solutions - chemistry</subject><ispartof>Drug discovery today, 2019-08, Vol.24 (8), p.1524-1538</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-4a1898c6379688e72645a127dd14ecfdca21cbceb55f9f10fb92da95db9d88173</citedby><cites>FETCH-LOGICAL-c463t-4a1898c6379688e72645a127dd14ecfdca21cbceb55f9f10fb92da95db9d88173</cites><orcidid>0000-0003-3191-0771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drudis.2019.05.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31102733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Tuo</creatorcontrib><creatorcontrib>Kulkarni, Vineet</creatorcontrib><creatorcontrib>Simmers, Russell</creatorcontrib><creatorcontrib>Brar, Vikram</creatorcontrib><creatorcontrib>Xu, Qingguo</creatorcontrib><title>Therapeutic implications of nanomedicine for ocular drug delivery</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>•Ocular nanomedicine with great clinical translational potential.•Nanomedicine can be used for treating anterior and posterior eye diseases.•The principles of nanomedicine for targeted and sustained ocular drug delivery.•The perspectives of ocular nanomedicine include scale-up manufacturing and safety profiles.
Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood–retinal barrier when drugs are administered systemically, and the cornea when drugs are administered topically, is difficult to achieve; limited drug penetration to the back of the eye owing to the cornea, conjunctiva, sclera and vitreous barriers. Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity. In this review, we highlight the therapeutic implications of nanomedicine for ocular drug delivery.
Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine can overcome ocular barriers, improve drug-release profiles and reduce potential drug toxicity.</description><subject>Animals</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems - methods</subject><subject>Eye - drug effects</subject><subject>Humans</subject><subject>Nanomedicine - methods</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmic Solutions - chemistry</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1KwzAUx4MoTqdvINIXaM1JkzS5EcbwCwbezOuQJumW0TUlbQd7ezumU2-8OgcO_4_zQ-gOcAYY-MMms3GwvssIBplhlmHMz9AViEKkTOTkfNxzJlNOKZ-g667bYAxEMn6JJjkAJkWeX6HZcu2ibt3Qe5P4bVt7o3sfmi4JVdLoJmyd9cY3LqlCTIIZah2TMXiVWFf7nYv7G3RR6bpzt19zij6en5bz13Tx_vI2ny1SQ3nep1SDkMLwvJBcCFcQTpkGUlgL1JnKGk3AlMaVjFWyAlyVklgtmS2lFQKKfIoej77tUI6ljGv6qGvVRr_Vca-C9urvpfFrtQo7xQsoGNDRgB4NTAxdF1110gJWB6Rqo45I1QGpwkyNSEfZ_e_ck-ib4U8xN36_8y6qznjXmBFcdKZXNvj_Ez4B6O2MbA</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Meng, Tuo</creator><creator>Kulkarni, Vineet</creator><creator>Simmers, Russell</creator><creator>Brar, Vikram</creator><creator>Xu, Qingguo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3191-0771</orcidid></search><sort><creationdate>20190801</creationdate><title>Therapeutic implications of nanomedicine for ocular drug delivery</title><author>Meng, Tuo ; Kulkarni, Vineet ; Simmers, Russell ; Brar, Vikram ; Xu, Qingguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-4a1898c6379688e72645a127dd14ecfdca21cbceb55f9f10fb92da95db9d88173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems - methods</topic><topic>Eye - drug effects</topic><topic>Humans</topic><topic>Nanomedicine - methods</topic><topic>Ophthalmic Solutions - administration & dosage</topic><topic>Ophthalmic Solutions - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Tuo</creatorcontrib><creatorcontrib>Kulkarni, Vineet</creatorcontrib><creatorcontrib>Simmers, Russell</creatorcontrib><creatorcontrib>Brar, Vikram</creatorcontrib><creatorcontrib>Xu, Qingguo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Tuo</au><au>Kulkarni, Vineet</au><au>Simmers, Russell</au><au>Brar, Vikram</au><au>Xu, Qingguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic implications of nanomedicine for ocular drug delivery</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>24</volume><issue>8</issue><spage>1524</spage><epage>1538</epage><pages>1524-1538</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>•Ocular nanomedicine with great clinical translational potential.•Nanomedicine can be used for treating anterior and posterior eye diseases.•The principles of nanomedicine for targeted and sustained ocular drug delivery.•The perspectives of ocular nanomedicine include scale-up manufacturing and safety profiles.
Delivering therapeutics to the eye is challenging on multiple levels: rapid clearance of eyedrops from the ocular surface requires frequent instillation, which is difficult for patients; transport of drugs across the blood–retinal barrier when drugs are administered systemically, and the cornea when drugs are administered topically, is difficult to achieve; limited drug penetration to the back of the eye owing to the cornea, conjunctiva, sclera and vitreous barriers. Nanomedicine offers many advantages over conventional ophthalmic medications for effective ocular drug delivery because nanomedicine can increase the therapeutic index by overcoming ocular barriers, improving drug-release profiles and reducing potential drug toxicity. In this review, we highlight the therapeutic implications of nanomedicine for ocular drug delivery.
Ocular nanomedicine poses a promising therapeutic potential and offers many advantages over conventional ophthalmic medications for effective ocular drug delivery; because nanomedicine can overcome ocular barriers, improve drug-release profiles and reduce potential drug toxicity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31102733</pmid><doi>10.1016/j.drudis.2019.05.006</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-3191-0771</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Drug Carriers - chemistry Drug Delivery Systems - methods Eye - drug effects Humans Nanomedicine - methods Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - chemistry |
| title | Therapeutic implications of nanomedicine for ocular drug delivery |
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