Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl⁻/H⁺ antiporter

The CLC family of proteins are involved in a variety of physiological processes to control cellular chloride concentration. Two distinct classes of CLC proteins, Cl⁻ channels and Cl⁻/H⁺ antiporters, have been functionally and structurally investigated over the last several decades. Previous studies...

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