Controlling the material properties and rRNA processing function of the nucleolus using light

The nucleolus is a prominent nuclear condensate that plays a central role in ribosome biogenesis by facilitating the transcription and processing of nascent ribosomal RNA (rRNA). A number of studies have highlighted the active viscoelastic nature of the nucleolus, whose material properties and phase...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-08, Vol.116 (35), p.17330-17335
Hauptverfasser:	Zhu, Lian, Richardson, Tiffany M., Wacheul, Ludivine, Wei, Ming-Tzo, Feric, Marina, Whitney, Gena, Lafontaine, Denis L. J., Brangwynne, Clifford P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biosynthesis Cell Nucleolus - metabolism Coalescing Depletion Material properties Mice Mobility Molecular interactions NIH 3T3 Cells Nucleoli Optogenetics Precursors Proteins RNA processing RNA Processing, Post-Transcriptional - physiology RNA, Ribosomal - metabolism rRNA Transcription Viscoelasticity Xenopus laevis
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