Intrinsic expression of viperin regulates thermogenesis in adipose tissues
Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that t...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2019-08, Vol.116 (35), p.17419-17428 |
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| creator | Eom, John Kim, Jeong Jin Yoon, Seul Gi Jeong, Haengdueng Son, Soojin Lee, Jae Bong Yoo, Jihye Seo, Hyun Ju Cho, Yejin Kim, Ku Sul Choi, Kyung Mi Kim, Il Yong Lee, Hui-Young Nam, Ki Taek Cresswell, Peter Seong, Je Kyung Seo, Jun-Young |
| description | Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts. |
| doi_str_mv | 10.1073/pnas.1904480116 |
| format | Article |
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Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1904480116</identifier><identifier>PMID: 31341090</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adipocytes - metabolism ; Adipose tissue ; Adipose Tissue - metabolism ; Animals ; Biological Sciences ; Body fat ; Cold tolerance ; Energy Metabolism - genetics ; Fatty acids ; Gene Expression Regulation ; Glucose tolerance ; High fat diet ; Interferon ; Male ; Metabolic disorders ; Mice ; Mice, Knockout ; Oxidation ; Phenotypes ; PNAS Plus ; Proteins ; Proteins - genetics ; Rodents ; Thermogenesis ; Thermogenesis - genetics ; Thermoregulation</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (35), p.17419-17428</ispartof><rights>Copyright National Academy of Sciences Aug 27, 2019</rights><rights>2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-792253d72aa32ea55c825e1cc49aa87a1a2102746a3dd0d5ea774b3139c92da83</citedby><cites>FETCH-LOGICAL-c443t-792253d72aa32ea55c825e1cc49aa87a1a2102746a3dd0d5ea774b3139c92da83</cites><orcidid>0000-0003-4004-2013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26850769$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26850769$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31341090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eom, John</creatorcontrib><creatorcontrib>Kim, Jeong Jin</creatorcontrib><creatorcontrib>Yoon, Seul Gi</creatorcontrib><creatorcontrib>Jeong, Haengdueng</creatorcontrib><creatorcontrib>Son, Soojin</creatorcontrib><creatorcontrib>Lee, Jae Bong</creatorcontrib><creatorcontrib>Yoo, Jihye</creatorcontrib><creatorcontrib>Seo, Hyun Ju</creatorcontrib><creatorcontrib>Cho, Yejin</creatorcontrib><creatorcontrib>Kim, Ku Sul</creatorcontrib><creatorcontrib>Choi, Kyung Mi</creatorcontrib><creatorcontrib>Kim, Il Yong</creatorcontrib><creatorcontrib>Lee, Hui-Young</creatorcontrib><creatorcontrib>Nam, Ki Taek</creatorcontrib><creatorcontrib>Cresswell, Peter</creatorcontrib><creatorcontrib>Seong, Je Kyung</creatorcontrib><creatorcontrib>Seo, Jun-Young</creatorcontrib><title>Intrinsic expression of viperin regulates thermogenesis in adipose tissues</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.</description><subject>Adipocytes - metabolism</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Biological Sciences</subject><subject>Body fat</subject><subject>Cold tolerance</subject><subject>Energy Metabolism - genetics</subject><subject>Fatty acids</subject><subject>Gene Expression Regulation</subject><subject>Glucose tolerance</subject><subject>High fat diet</subject><subject>Interferon</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Oxidation</subject><subject>Phenotypes</subject><subject>PNAS Plus</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>Rodents</subject><subject>Thermogenesis</subject><subject>Thermogenesis - genetics</subject><subject>Thermoregulation</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1P3DAUxK2Kqmxpzz0VReLSS8BfseMLEkK0gJB6ac_Ww3m7eJWNg1-C2v8eo6VL4WIf5vdGMxrGvgh-LLhVJ-MAdCwc17rlQph3bCG4E7XRju-xBefS1q2Wep99JFpzzl3T8g9sXwmlC8gX7PpqmHIcKIYK_4wZiWIaqrSsHuKIRagyruYeJqRqusO8SSsckCJVRYIujomwmiLRjPSJvV9CT_j5-T9gv79f_Dq_rG9-_rg6P7upg9Zqqq2TslGdlQBKIjRNaGWDIgTtAFoLAqQoubUB1XW8axCs1bclsQtOdtCqA3a69R3n2w12AUsD6P2Y4wbyX58g-tfKEO_8Kj14Y4WVpikG354NcrovwSe_iRSw72HANJOX0mhZHmELevQGXac5D6VeoVqllDBWF-pkS4WciDIud2EE9087-aed_MtO5eLw_w47_t8wBfi6BdY0pbzTpWkbbo1Tj0X4mXc</recordid><startdate>20190827</startdate><enddate>20190827</enddate><creator>Eom, John</creator><creator>Kim, Jeong Jin</creator><creator>Yoon, Seul Gi</creator><creator>Jeong, Haengdueng</creator><creator>Son, Soojin</creator><creator>Lee, Jae Bong</creator><creator>Yoo, Jihye</creator><creator>Seo, Hyun Ju</creator><creator>Cho, Yejin</creator><creator>Kim, Ku Sul</creator><creator>Choi, Kyung Mi</creator><creator>Kim, Il Yong</creator><creator>Lee, Hui-Young</creator><creator>Nam, Ki Taek</creator><creator>Cresswell, Peter</creator><creator>Seong, Je Kyung</creator><creator>Seo, Jun-Young</creator><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4004-2013</orcidid></search><sort><creationdate>20190827</creationdate><title>Intrinsic expression of viperin regulates thermogenesis in adipose tissues</title><author>Eom, John ; 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Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter metabolic disease and contribute to the febrile response to pathogen invasion. Viperin knockout mice exhibit increased heat production, resulting in a reduction of fat mass, improvement of high-fat diet (HFD)-induced glucose tolerance, and enhancement of cold tolerance. These thermogenic phenotypes are attributed to an adipocyte-autonomous mechanism that regulates fatty acid β-oxidation. Under an HFD, viperin expression is increased, and its function is enhanced. Our findings reveal the intrinsic function of viperin as a novel mechanism regulating thermogenesis in adipose tissues, suggesting that viperin represents a molecular target for thermoregulation in clinical contexts.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>31341090</pmid><doi>10.1073/pnas.1904480116</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4004-2013</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes - metabolism Adipose tissue Adipose Tissue - metabolism Animals Biological Sciences Body fat Cold tolerance Energy Metabolism - genetics Fatty acids Gene Expression Regulation Glucose tolerance High fat diet Interferon Male Metabolic disorders Mice Mice, Knockout Oxidation Phenotypes PNAS Plus Proteins Proteins - genetics Rodents Thermogenesis Thermogenesis - genetics Thermoregulation |
| title | Intrinsic expression of viperin regulates thermogenesis in adipose tissues |
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