Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis
A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2019, Vol.81(8), pp.1177-1181 |
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| creator | MATIZ, Oscar Rodrigo SIERRA VIERA, Rafaela Bortolotti JARK, Paulo Cesar ANJOS, Denner Santos DOS MONTEIRO, Julio Edward Hough MATSUI, Andresa VASCONCELOS, Rosemeri de Oliveira SUEIRO, Felipe Ruiz CALAZANS, Sabryna Gouveia TINUCCI-COSTA, Mirela |
| description | A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient. |
| doi_str_mv | 10.1292/jvms.18-0594 |
| format | Article |
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Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.18-0594</identifier><identifier>PMID: 31167982</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Amputation - veterinary ; Animals ; Biomarkers, Tumor ; Bone Neoplasms - drug therapy ; Bone Neoplasms - secondary ; Bone Neoplasms - surgery ; Bone Neoplasms - veterinary ; canine ; carcinoma of unknown primary ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Carcinoma, Squamous Cell - veterinary ; Dogs ; Drug Therapy - veterinary ; Female ; Immunohistochemistry ; Internal Medicine ; Keratins - metabolism ; Kidney Neoplasms - secondary ; Kidney Neoplasms - veterinary ; Lung Neoplasms - secondary ; Lung Neoplasms - veterinary ; metastatic cancer ; neoplasm ; Neoplasms, Unknown Primary - drug therapy ; Neoplasms, Unknown Primary - surgery ; Neoplasms, Unknown Primary - veterinary ; Scapula - metabolism ; Scapula - pathology ; Scapula - surgery ; Vimentin - metabolism</subject><ispartof>Journal of Veterinary Medical Science, 2019, Vol.81(8), pp.1177-1181</ispartof><rights>2019 by the Japanese Society of Veterinary Science</rights><rights>2019 The Japanese Society of Veterinary Science 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-f1710f0dda79f99b12bd79ff0c36eae6101b502e06df51028c2bf5e827219c83</citedby><cites>FETCH-LOGICAL-c533t-f1710f0dda79f99b12bd79ff0c36eae6101b502e06df51028c2bf5e827219c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715932/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715932/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,4010,27904,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31167982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATIZ, Oscar Rodrigo SIERRA</creatorcontrib><creatorcontrib>VIERA, Rafaela Bortolotti</creatorcontrib><creatorcontrib>JARK, Paulo Cesar</creatorcontrib><creatorcontrib>ANJOS, Denner Santos DOS</creatorcontrib><creatorcontrib>MONTEIRO, Julio Edward Hough</creatorcontrib><creatorcontrib>MATSUI, Andresa</creatorcontrib><creatorcontrib>VASCONCELOS, Rosemeri de Oliveira</creatorcontrib><creatorcontrib>SUEIRO, Felipe Ruiz</creatorcontrib><creatorcontrib>CALAZANS, Sabryna Gouveia</creatorcontrib><creatorcontrib>TINUCCI-COSTA, Mirela</creatorcontrib><title>Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient.</description><subject>Amputation - veterinary</subject><subject>Animals</subject><subject>Biomarkers, Tumor</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - surgery</subject><subject>Bone Neoplasms - veterinary</subject><subject>canine</subject><subject>carcinoma of unknown primary</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Carcinoma, Squamous Cell - veterinary</subject><subject>Dogs</subject><subject>Drug Therapy - veterinary</subject><subject>Female</subject><subject>Immunohistochemistry</subject><subject>Internal Medicine</subject><subject>Keratins - metabolism</subject><subject>Kidney Neoplasms - secondary</subject><subject>Kidney Neoplasms - veterinary</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - veterinary</subject><subject>metastatic cancer</subject><subject>neoplasm</subject><subject>Neoplasms, Unknown Primary - drug therapy</subject><subject>Neoplasms, Unknown Primary - surgery</subject><subject>Neoplasms, Unknown Primary - veterinary</subject><subject>Scapula - metabolism</subject><subject>Scapula - pathology</subject><subject>Scapula - surgery</subject><subject>Vimentin - metabolism</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFv3CAQhVHVqtmmvfVcceyhThkwBi6VmqhNI0XqITnlgjDGXrY2JGAnyr8v1m5WrTQCxHx6M3oPoY9AzoAq-nX3OOUzkBXhqn6FNsBqUYmaqddoQxQ0laCcnKB3Oe8IoVA36i06YQCNUJJu0N3Nw2KmuGRs3Thia5L1IU4Gxx4v4U-ITwHfJz-Z9Ixj8oMPuJTBXRzKv8suzD4M-MnPW9zG4PDkZpNL-fwevenNmN2Hw32Kbn_-uL34VV3_vry6-H5dWc7YXPUggPSk64xQvVIt0LYrr55Y1jjjGiDQckIdabqeA6HS0rbnTlJBQVnJTtG3vez90k6us2WjZEZ9WFpH4_X_neC3eoiPuhHAFaNF4PNBIMWHxeVZTz6vbpjgijGaUkm4UDUXBf2yR22KOSfXH8cA0Wsaek1Dg9RrGgX_9O9qR_jF_gKc74FdsWxwR8Ck2dvR7dUkaLkeB9Vj025N0i6wv1J7oLE</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>MATIZ, Oscar Rodrigo SIERRA</creator><creator>VIERA, Rafaela Bortolotti</creator><creator>JARK, Paulo Cesar</creator><creator>ANJOS, Denner Santos DOS</creator><creator>MONTEIRO, Julio Edward Hough</creator><creator>MATSUI, Andresa</creator><creator>VASCONCELOS, Rosemeri de Oliveira</creator><creator>SUEIRO, Felipe Ruiz</creator><creator>CALAZANS, Sabryna Gouveia</creator><creator>TINUCCI-COSTA, Mirela</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2019</creationdate><title>Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis</title><author>MATIZ, Oscar Rodrigo SIERRA ; VIERA, Rafaela Bortolotti ; JARK, Paulo Cesar ; ANJOS, Denner Santos DOS ; MONTEIRO, Julio Edward Hough ; MATSUI, Andresa ; VASCONCELOS, Rosemeri de Oliveira ; SUEIRO, Felipe Ruiz ; CALAZANS, Sabryna Gouveia ; TINUCCI-COSTA, Mirela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-f1710f0dda79f99b12bd79ff0c36eae6101b502e06df51028c2bf5e827219c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amputation - veterinary</topic><topic>Animals</topic><topic>Biomarkers, Tumor</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Neoplasms - surgery</topic><topic>Bone Neoplasms - veterinary</topic><topic>canine</topic><topic>carcinoma of unknown primary</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Carcinoma, Squamous Cell - veterinary</topic><topic>Dogs</topic><topic>Drug Therapy - veterinary</topic><topic>Female</topic><topic>Immunohistochemistry</topic><topic>Internal Medicine</topic><topic>Keratins - metabolism</topic><topic>Kidney Neoplasms - secondary</topic><topic>Kidney Neoplasms - veterinary</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - veterinary</topic><topic>metastatic cancer</topic><topic>neoplasm</topic><topic>Neoplasms, Unknown Primary - drug therapy</topic><topic>Neoplasms, Unknown Primary - surgery</topic><topic>Neoplasms, Unknown Primary - veterinary</topic><topic>Scapula - metabolism</topic><topic>Scapula - pathology</topic><topic>Scapula - surgery</topic><topic>Vimentin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MATIZ, Oscar Rodrigo SIERRA</creatorcontrib><creatorcontrib>VIERA, Rafaela Bortolotti</creatorcontrib><creatorcontrib>JARK, Paulo Cesar</creatorcontrib><creatorcontrib>ANJOS, Denner Santos DOS</creatorcontrib><creatorcontrib>MONTEIRO, Julio Edward Hough</creatorcontrib><creatorcontrib>MATSUI, Andresa</creatorcontrib><creatorcontrib>VASCONCELOS, Rosemeri de Oliveira</creatorcontrib><creatorcontrib>SUEIRO, Felipe Ruiz</creatorcontrib><creatorcontrib>CALAZANS, Sabryna Gouveia</creatorcontrib><creatorcontrib>TINUCCI-COSTA, Mirela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATIZ, Oscar Rodrigo SIERRA</au><au>VIERA, Rafaela Bortolotti</au><au>JARK, Paulo Cesar</au><au>ANJOS, Denner Santos DOS</au><au>MONTEIRO, Julio Edward Hough</au><au>MATSUI, Andresa</au><au>VASCONCELOS, Rosemeri de Oliveira</au><au>SUEIRO, Felipe Ruiz</au><au>CALAZANS, Sabryna Gouveia</au><au>TINUCCI-COSTA, Mirela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2019</date><risdate>2019</risdate><volume>81</volume><issue>8</issue><spage>1177</spage><epage>1181</epage><pages>1177-1181</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>31167982</pmid><doi>10.1292/jvms.18-0594</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Veterinary Medical Science, 2019, Vol.81(8), pp.1177-1181 |
| issn | 0916-7250 1347-7439 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Amputation - veterinary Animals Biomarkers, Tumor Bone Neoplasms - drug therapy Bone Neoplasms - secondary Bone Neoplasms - surgery Bone Neoplasms - veterinary canine carcinoma of unknown primary Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Carcinoma, Squamous Cell - veterinary Dogs Drug Therapy - veterinary Female Immunohistochemistry Internal Medicine Keratins - metabolism Kidney Neoplasms - secondary Kidney Neoplasms - veterinary Lung Neoplasms - secondary Lung Neoplasms - veterinary metastatic cancer neoplasm Neoplasms, Unknown Primary - drug therapy Neoplasms, Unknown Primary - surgery Neoplasms, Unknown Primary - veterinary Scapula - metabolism Scapula - pathology Scapula - surgery Vimentin - metabolism |
| title | Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis |
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