The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity

Multiple sclerosis (MS) is a putative T cell-mediated autoimmune disease. As with many autoimmune diseases, females are more susceptible than males. Sexual dimorphisms may be due to differences in sex hormones, sex chromosomes, or both. Regarding sex chromosome genes, a small percentage of X chromos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2019-09, Vol.129 (9), p.3852-3863
Hauptverfasser:	Itoh, Yuichiro, Golden, Lisa C, Itoh, Noriko, Matsukawa, Macy Akiyo, Ren, Emily, Tse, Vincent, Arnold, Arthur P, Voskuhl, Rhonda R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases Autoimmunity - immunology Bioinformatics Biomedical research CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chromosomes Clonal deletion Compensation Disease Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - immunology Experimental allergic encephalomyelitis Female Females Gender differences Gene Deletion Gene expression Gene Expression Profiling Genes, X-Linked Genomes Genotype Genotypes Histone Demethylases - genetics Histones - metabolism Hormones Humans Hyaluronan Receptors - metabolism Inflammation Lymphocytes Lymphocytes T Male Males Mammals Menopause Mice Mice, Knockout Multiple sclerosis Multiple Sclerosis - metabolism Phenotype Sex chromosomes Sex differences Sex hormones Sexual dimorphism Stem cells Th1 Cells - metabolism Th2 Cells - metabolism Transcriptome X chromosomes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!