N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration resistant prostate cancers become androgen receptor (AR) signaling-independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEP...

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Veröffentlicht in:	The Journal of clinical investigation 2019-09, Vol.129 (9), p.3924-3940
Hauptverfasser:	Berger, Adeline, Brady, Nicholas J, Bareja, Rohan, Robinson, Brian, Conteduca, Vincenza, Augello, Michael A, Puca, Loredana, Ahmed, Adnan, Dardenne, Etienne, Lu, Xiaodong, Hwang, Inah, Bagadion, Alyssa M, Sboner, Andrea, Elemento, Olivier, Paik, Jihye, Yu, Jindan, Barbieri, Christopher E, Dephoure, Noah, Beltran, Himisha, Rickman, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Androgen receptors Androgens Animals Bioinformatics Biomedical research Castration Cell cycle Cell Line, Tumor Cell Lineage Cell Plasticity Cofactors Death Development and progression DNA - chemistry Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Gene Expression Regulation, Neoplastic Genes Genomes Health aspects Humans Male Medical prognosis Metastasis Mice Mice, Transgenic Myc protein N-Myc Proto-Oncogene Protein - genetics N-Myc Proto-Oncogene Protein - metabolism Neoplasm Transplantation Neuroblastoma Organoids Patients Prognosis Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - metabolism Receptors, Androgen - genetics Scientific equipment industry Signal Transduction Stem cells Transcription factors Transcriptome Tumors
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