β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion

Beta-arrestin-1 and -2 (Barr1 and Barr2, respectively) are intracellular signaling molecules that regulate many important metabolic functions. We previously demonstrated that mice lacking Barr2 selectively in pancreatic beta-cells showed pronounced metabolic impairments. Here we investigated whether...

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Veröffentlicht in:The Journal of clinical investigation 2019-09, Vol.130 (9), p.3732-3737
Hauptverfasser: Barella, Luiz F, Rossi, Mario, Zhu, Lu, Cui, Yinghong, Mei, Fang C, Cheng, Xiaodong, Chen, Wei, Gurevich, Vsevolod V, Wess, Jürgen
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