Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer
We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order co...
Gespeichert in:
| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2018-07, Vol.24 (5), p.755-763 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 763 |
|---|---|
| container_issue | 5 |
| container_start_page | 755 |
| container_title | Clinical and applied thrombosis/hemostasis |
| container_volume | 24 |
| creator | Wang, Zhengwei Li, Jing Cao, Qingwei Wang, Lei Shan, Fengzhi Zhang, Houyi |
| description | We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test (P = .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test (P = .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time–international normalized ratio (PT-INR) and negatively correlated with FIB (P < .001). Contrarily, α-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer. |
| doi_str_mv | 10.1177/1076029617724229 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6714867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1076029617724229</sage_id><sourcerecordid>2313718657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-7af5a1555f1d9bda206e7e7d1da77f5699c4f5a3f905e5f7b91233d676acc83a3</originalsourceid><addsrcrecordid>eNp1UU2L1TAUDaI44-jelQTcuKnmo0majeAUv-CBAz5xGe5L074MbfJM2pER_O-mvHHUAVe5N-fccz8OQk8peUmpUq8oUZIwLUvMasb0PXRKNW8qphi_X-ICVyt-gh7lfEkI1VLLh-iENY0ipKlP0c82TgdIPseAz9383bmAt_sUp110I-Q5DgkO-2sMocNtDFcuzD4GGEsCwzLCmuGty3PGPuDPSxq8LehFAQo1469-3uNNLH_-h-vwRYp5htnhFoJ16TF60MOY3ZOb9wx9efd2236oNp_ef2zfbCpbSzZXCnoBVAjR007vOmBEOuVURztQqhdSa1sXBu81EU70aqcp47yTSoK1DQd-hl4fdQ_LbnKdLaMlGM0h-QnStYngzb9I8HszxCsjFa0bqYrAixuBFL8tZV0z-WzdOEJwccmmXF00dLWgUJ_foV7GJZWTZcM45Yo2UqyC5Miy5SI5uf52GErM6q25620pefb3ErcFv80shOpIyDC4P13_K_gLPMmvDw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2313718657</pqid></control><display><type>article</type><title>Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer</title><source>Sage Journals GOLD Open Access 2024</source><creator>Wang, Zhengwei ; Li, Jing ; Cao, Qingwei ; Wang, Lei ; Shan, Fengzhi ; Zhang, Houyi</creator><creatorcontrib>Wang, Zhengwei ; Li, Jing ; Cao, Qingwei ; Wang, Lei ; Shan, Fengzhi ; Zhang, Houyi</creatorcontrib><description>We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test (P = .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test (P = .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time–international normalized ratio (PT-INR) and negatively correlated with FIB (P < .001). Contrarily, α-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029617724229</identifier><identifier>PMID: 28870084</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Blood Coagulation Tests - standards ; Hemorrhage - diagnosis ; Hemorrhage - etiology ; Humans ; Male ; Middle Aged ; Original ; Postoperative Hemorrhage - diagnosis ; Postoperative Hemorrhage - etiology ; Predictive Value of Tests ; Prostate cancer ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - surgery ; Sensitivity and Specificity ; Thrombelastography - standards ; Thrombosis ; Thrombosis - diagnosis ; Thrombosis - etiology</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2018-07, Vol.24 (5), p.755-763</ispartof><rights>The Author(s) 2017</rights><rights>The Author(s) 2017. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>The Author(s) 2017 2017 SAGE Publications Inc. unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-7af5a1555f1d9bda206e7e7d1da77f5699c4f5a3f905e5f7b91233d676acc83a3</citedby><cites>FETCH-LOGICAL-c462t-7af5a1555f1d9bda206e7e7d1da77f5699c4f5a3f905e5f7b91233d676acc83a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714867/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714867/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21964,27851,27922,27923,44943,45331,53789,53791</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029617724229?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28870084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhengwei</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Cao, Qingwei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Shan, Fengzhi</creatorcontrib><creatorcontrib>Zhang, Houyi</creatorcontrib><title>Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test (P = .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test (P = .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time–international normalized ratio (PT-INR) and negatively correlated with FIB (P < .001). Contrarily, α-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Coagulation Tests - standards</subject><subject>Hemorrhage - diagnosis</subject><subject>Hemorrhage - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Postoperative Hemorrhage - diagnosis</subject><subject>Postoperative Hemorrhage - etiology</subject><subject>Predictive Value of Tests</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Sensitivity and Specificity</subject><subject>Thrombelastography - standards</subject><subject>Thrombosis</subject><subject>Thrombosis - diagnosis</subject><subject>Thrombosis - etiology</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UU2L1TAUDaI44-jelQTcuKnmo0majeAUv-CBAz5xGe5L074MbfJM2pER_O-mvHHUAVe5N-fccz8OQk8peUmpUq8oUZIwLUvMasb0PXRKNW8qphi_X-ICVyt-gh7lfEkI1VLLh-iENY0ipKlP0c82TgdIPseAz9383bmAt_sUp110I-Q5DgkO-2sMocNtDFcuzD4GGEsCwzLCmuGty3PGPuDPSxq8LehFAQo1469-3uNNLH_-h-vwRYp5htnhFoJ16TF60MOY3ZOb9wx9efd2236oNp_ef2zfbCpbSzZXCnoBVAjR007vOmBEOuVURztQqhdSa1sXBu81EU70aqcp47yTSoK1DQd-hl4fdQ_LbnKdLaMlGM0h-QnStYngzb9I8HszxCsjFa0bqYrAixuBFL8tZV0z-WzdOEJwccmmXF00dLWgUJ_foV7GJZWTZcM45Yo2UqyC5Miy5SI5uf52GErM6q25620pefb3ErcFv80shOpIyDC4P13_K_gLPMmvDw</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Wang, Zhengwei</creator><creator>Li, Jing</creator><creator>Cao, Qingwei</creator><creator>Wang, Lei</creator><creator>Shan, Fengzhi</creator><creator>Zhang, Houyi</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer</title><author>Wang, Zhengwei ; Li, Jing ; Cao, Qingwei ; Wang, Lei ; Shan, Fengzhi ; Zhang, Houyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-7af5a1555f1d9bda206e7e7d1da77f5699c4f5a3f905e5f7b91233d676acc83a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Coagulation Tests - standards</topic><topic>Hemorrhage - diagnosis</topic><topic>Hemorrhage - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Postoperative Hemorrhage - diagnosis</topic><topic>Postoperative Hemorrhage - etiology</topic><topic>Predictive Value of Tests</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Sensitivity and Specificity</topic><topic>Thrombelastography - standards</topic><topic>Thrombosis</topic><topic>Thrombosis - diagnosis</topic><topic>Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhengwei</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Cao, Qingwei</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Shan, Fengzhi</creatorcontrib><creatorcontrib>Zhang, Houyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wang, Zhengwei</au><au>Li, Jing</au><au>Cao, Qingwei</au><au>Wang, Lei</au><au>Shan, Fengzhi</au><au>Zhang, Houyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>24</volume><issue>5</issue><spage>755</spage><epage>763</epage><pages>755-763</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test (P = .024). Overall, 60 patients did not have active bleeding postoperatively, 51 of whom showed hypercoagulation detected by TEG test and 42 of whom showed hypercoagulation found by routine coagulation test (P = .040). Remarkably, patients had a little higher fibrinogen (FIB) compared to controls. There was no statistical difference in any of the conventional coagulation indexes between the groups. Correlation analysis showed that reaction time (R) and coagulation time (K) were positively correlated with the prothrombin time–international normalized ratio (PT-INR) and negatively correlated with FIB (P < .001). Contrarily, α-angle and maximum amplitude (MA) were negatively correlated with PT-INR but positively correlated with FIB. Significantly, MA showed the strongest correlation with FIB and R exhibited the strongest correlation with PT-INR. Sensitivity and specificity for bleeding and thrombosis in TEG were higher than those in conventional coagulation test. Accordingly, TEG might be superior in evaluating hypercoagulation and detecting the risk of bleeding in patients with prostate cancer.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28870084</pmid><doi>10.1177/1076029617724229</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2018-07, Vol.24 (5), p.755-763 |
| issn | 1076-0296 1938-2723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6714867 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Aged Blood Coagulation Tests - standards Hemorrhage - diagnosis Hemorrhage - etiology Humans Male Middle Aged Original Postoperative Hemorrhage - diagnosis Postoperative Hemorrhage - etiology Predictive Value of Tests Prostate cancer Prostatic Neoplasms - complications Prostatic Neoplasms - surgery Sensitivity and Specificity Thrombelastography - standards Thrombosis Thrombosis - diagnosis Thrombosis - etiology |
| title | Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T05%3A41%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20Between%20Thromboelastography%20and%20Conventional%20Coagulation%20Tests%20in%20Surgical%20Patients%20With%20Localized%20Prostate%20Cancer&rft.jtitle=Clinical%20and%20applied%20thrombosis/hemostasis&rft.au=Wang,%20Zhengwei&rft.date=2018-07-01&rft.volume=24&rft.issue=5&rft.spage=755&rft.epage=763&rft.pages=755-763&rft.issn=1076-0296&rft.eissn=1938-2723&rft_id=info:doi/10.1177/1076029617724229&rft_dat=%3Cproquest_AFRWT%3E2313718657%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2313718657&rft_id=info:pmid/28870084&rft_sage_id=10.1177_1076029617724229&rfr_iscdi=true |