The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery
Objective: The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated. Materials and Methods: Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) b...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2018-01, Vol.24 (1), p.107-114 |
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| creator | Hasegawa, Masahiro Wada, Hideo Miyazaki, Shinichi Yamaguchi, Toshio Wakabayashi, Hiroki Fujimoto, Naoki Matsumoto, Takeshi Ohishi, Kohshi Sakaguchi, Akane Yamada, Norikazu Ito, Masaaki Yamashita, Yoshiki Katayama, Naoyuki Nakatani, Kaname Sudo, Akihiro |
| description | Objective:
The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated.
Materials and Methods:
Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE.
Results:
Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 μg/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 μg/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 μg/mL), and for excluding VTE.
Conclusion:
Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE. |
| doi_str_mv | 10.1177/1076029616674824 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6714636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1076029616674824</sage_id><sourcerecordid>1878819900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-1c6ab84386752f544d9c12b44741c6f79c2d12787b3ecdd77760680a7acae6573</originalsourceid><addsrcrecordid>eNp1UU1v1DAQjRCIlsKdE7LEhUuK7Tj-uCBVpYVKrVrBlqvlOJOsl8Re7KRSfw7_FEdbCq3Ug-WZeW_efBXFW4IPCRHiI8GCY6o44VwwSdmzYp-oSpZU0Op5tjNcLvhe8SqlDcZEccVfFntUVtnGdL_4vVoDOrkxw2wmFzwKHTp1TXS-_AaDmaBFFyb-hJhQFyL67EzvQ3K-R9m7itA6Oy3ekZ0nWGLf58YOzjtrBvQDfJgTWq1jGJsA-Q0ujch5dJWLgZ8SuvYtxD4sEhdmk_Mv47QO20U3S8Ue4u3r4kVnhgRv7v6D4vr0ZHX8tTy__HJ2fHRe2prKqSSWm0aySnJR065mrFWW0IYxwTLUCWVpS6iQoqnAtq0QeXNcYiOMNcBrUR0Un3a627kZobW5v2gGvY1uNPFWB-P0Q8S7te7DjeaCMF7xLPDhTiCGXzOkSY8uWRgG4yHvQRMppCRKYZyp7x9RN2GOPo-naUUqQWStWGbhHcvGkFKE7r4ZgvVyf_34_jnl3f9D3Cf8PXgmlDtCMj38q_qk4B_mxbrK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2313718594</pqid></control><display><type>article</type><title>The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery</title><source>Sage Journals GOLD Open Access 2024</source><creator>Hasegawa, Masahiro ; Wada, Hideo ; Miyazaki, Shinichi ; Yamaguchi, Toshio ; Wakabayashi, Hiroki ; Fujimoto, Naoki ; Matsumoto, Takeshi ; Ohishi, Kohshi ; Sakaguchi, Akane ; Yamada, Norikazu ; Ito, Masaaki ; Yamashita, Yoshiki ; Katayama, Naoyuki ; Nakatani, Kaname ; Sudo, Akihiro</creator><creatorcontrib>Hasegawa, Masahiro ; Wada, Hideo ; Miyazaki, Shinichi ; Yamaguchi, Toshio ; Wakabayashi, Hiroki ; Fujimoto, Naoki ; Matsumoto, Takeshi ; Ohishi, Kohshi ; Sakaguchi, Akane ; Yamada, Norikazu ; Ito, Masaaki ; Yamashita, Yoshiki ; Katayama, Naoyuki ; Nakatani, Kaname ; Sudo, Akihiro</creatorcontrib><description>Objective:
The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated.
Materials and Methods:
Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE.
Results:
Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 μg/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 μg/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 μg/mL), and for excluding VTE.
Conclusion:
Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029616674824</identifier><identifier>PMID: 28301902</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Acute Disease ; Aged ; Biomarkers - blood ; Bone surgery ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; Fibrinogen - metabolism ; Health risk assessment ; Humans ; Male ; Middle Aged ; Original ; Orthopedic Procedures - adverse effects ; Orthopedics ; Postoperative Complications - blood ; Thromboembolism ; Venous Thromboembolism - blood ; Venous Thromboembolism - etiology</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2018-01, Vol.24 (1), p.107-114</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>The Author(s) 2016 2016 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-1c6ab84386752f544d9c12b44741c6f79c2d12787b3ecdd77760680a7acae6573</citedby><cites>FETCH-LOGICAL-c528t-1c6ab84386752f544d9c12b44741c6f79c2d12787b3ecdd77760680a7acae6573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714636/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714636/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029616674824?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28301902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Wada, Hideo</creatorcontrib><creatorcontrib>Miyazaki, Shinichi</creatorcontrib><creatorcontrib>Yamaguchi, Toshio</creatorcontrib><creatorcontrib>Wakabayashi, Hiroki</creatorcontrib><creatorcontrib>Fujimoto, Naoki</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Ohishi, Kohshi</creatorcontrib><creatorcontrib>Sakaguchi, Akane</creatorcontrib><creatorcontrib>Yamada, Norikazu</creatorcontrib><creatorcontrib>Ito, Masaaki</creatorcontrib><creatorcontrib>Yamashita, Yoshiki</creatorcontrib><creatorcontrib>Katayama, Naoyuki</creatorcontrib><creatorcontrib>Nakatani, Kaname</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><title>The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Objective:
The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated.
Materials and Methods:
Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE.
Results:
Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 μg/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 μg/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 μg/mL), and for excluding VTE.
Conclusion:
Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Bone surgery</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Fibrinogen - metabolism</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Orthopedic Procedures - adverse effects</subject><subject>Orthopedics</subject><subject>Postoperative Complications - blood</subject><subject>Thromboembolism</subject><subject>Venous Thromboembolism - blood</subject><subject>Venous Thromboembolism - etiology</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UU1v1DAQjRCIlsKdE7LEhUuK7Tj-uCBVpYVKrVrBlqvlOJOsl8Re7KRSfw7_FEdbCq3Ug-WZeW_efBXFW4IPCRHiI8GCY6o44VwwSdmzYp-oSpZU0Op5tjNcLvhe8SqlDcZEccVfFntUVtnGdL_4vVoDOrkxw2wmFzwKHTp1TXS-_AaDmaBFFyb-hJhQFyL67EzvQ3K-R9m7itA6Oy3ekZ0nWGLf58YOzjtrBvQDfJgTWq1jGJsA-Q0ujch5dJWLgZ8SuvYtxD4sEhdmk_Mv47QO20U3S8Ue4u3r4kVnhgRv7v6D4vr0ZHX8tTy__HJ2fHRe2prKqSSWm0aySnJR065mrFWW0IYxwTLUCWVpS6iQoqnAtq0QeXNcYiOMNcBrUR0Un3a627kZobW5v2gGvY1uNPFWB-P0Q8S7te7DjeaCMF7xLPDhTiCGXzOkSY8uWRgG4yHvQRMppCRKYZyp7x9RN2GOPo-naUUqQWStWGbhHcvGkFKE7r4ZgvVyf_34_jnl3f9D3Cf8PXgmlDtCMj38q_qk4B_mxbrK</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Hasegawa, Masahiro</creator><creator>Wada, Hideo</creator><creator>Miyazaki, Shinichi</creator><creator>Yamaguchi, Toshio</creator><creator>Wakabayashi, Hiroki</creator><creator>Fujimoto, Naoki</creator><creator>Matsumoto, Takeshi</creator><creator>Ohishi, Kohshi</creator><creator>Sakaguchi, Akane</creator><creator>Yamada, Norikazu</creator><creator>Ito, Masaaki</creator><creator>Yamashita, Yoshiki</creator><creator>Katayama, Naoyuki</creator><creator>Nakatani, Kaname</creator><creator>Sudo, Akihiro</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery</title><author>Hasegawa, Masahiro ; Wada, Hideo ; Miyazaki, Shinichi ; Yamaguchi, Toshio ; Wakabayashi, Hiroki ; Fujimoto, Naoki ; Matsumoto, Takeshi ; Ohishi, Kohshi ; Sakaguchi, Akane ; Yamada, Norikazu ; Ito, Masaaki ; Yamashita, Yoshiki ; Katayama, Naoyuki ; Nakatani, Kaname ; Sudo, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-1c6ab84386752f544d9c12b44741c6f79c2d12787b3ecdd77760680a7acae6573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Bone surgery</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Fibrinogen - metabolism</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Orthopedic Procedures - adverse effects</topic><topic>Orthopedics</topic><topic>Postoperative Complications - blood</topic><topic>Thromboembolism</topic><topic>Venous Thromboembolism - blood</topic><topic>Venous Thromboembolism - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Wada, Hideo</creatorcontrib><creatorcontrib>Miyazaki, Shinichi</creatorcontrib><creatorcontrib>Yamaguchi, Toshio</creatorcontrib><creatorcontrib>Wakabayashi, Hiroki</creatorcontrib><creatorcontrib>Fujimoto, Naoki</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Ohishi, Kohshi</creatorcontrib><creatorcontrib>Sakaguchi, Akane</creatorcontrib><creatorcontrib>Yamada, Norikazu</creatorcontrib><creatorcontrib>Ito, Masaaki</creatorcontrib><creatorcontrib>Yamashita, Yoshiki</creatorcontrib><creatorcontrib>Katayama, Naoyuki</creatorcontrib><creatorcontrib>Nakatani, Kaname</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Hasegawa, Masahiro</au><au>Wada, Hideo</au><au>Miyazaki, Shinichi</au><au>Yamaguchi, Toshio</au><au>Wakabayashi, Hiroki</au><au>Fujimoto, Naoki</au><au>Matsumoto, Takeshi</au><au>Ohishi, Kohshi</au><au>Sakaguchi, Akane</au><au>Yamada, Norikazu</au><au>Ito, Masaaki</au><au>Yamashita, Yoshiki</au><au>Katayama, Naoyuki</au><au>Nakatani, Kaname</au><au>Sudo, Akihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>24</volume><issue>1</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Objective:
The cutoff values of fibrin-related markers (FRMs) diagnosing or predicting the occurrence of a venous thromboembolism (VTE) were evaluated.
Materials and Methods:
Fibrin-related markers such as fibrin monomer complex (FMC), D-dimer, and fibrinogen and fibrin degradation products (FDPs) before surgery were measured in 326 patients undergoing orthopedic surgery to diagnose subclinical VTE or predict postoperative VTE.
Results:
Although the FMC, D-dimer, and FDP levels were all useful for the diagnosis of acute VTE, the FDP level was not useful for diagnosing subclinical VTE or predicting postoperative VTE. The results of several D-dimer assays closely correlated with other D-dimer assays. There were various cutoff ranges for diagnosing or predicting VTE. Some D-dimer assays were useful for diagnosing low levels of D-dimer and others were useful for diagnosing moderate to high D-dimer levels. Increased D-dimer levels were useful for diagnosing acute (cutoff values: 2.0-5.9 μg/mL) or about 10% of subclinical VTE (cutoff values: 3.4-5.3 μg/mL), for predicting about 10% of postoperative VTE (cutoff values: 3.4-5.3 μg/mL), and for excluding VTE.
Conclusion:
Although increased D-dimer levels were useful for diagnosing subclinical VTE and predicting the risk of VTE, there were various cutoff values for the diagnosis or prediction of VTE.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28301902</pmid><doi>10.1177/1076029616674824</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2018-01, Vol.24 (1), p.107-114 |
| issn | 1076-0296 1938-2723 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6714636 |
| source | Sage Journals GOLD Open Access 2024 |
| subjects | Acute Disease Aged Biomarkers - blood Bone surgery Female Fibrin Fibrinogen Degradation Products - metabolism Fibrinogen - metabolism Health risk assessment Humans Male Middle Aged Original Orthopedic Procedures - adverse effects Orthopedics Postoperative Complications - blood Thromboembolism Venous Thromboembolism - blood Venous Thromboembolism - etiology |
| title | The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery |
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