Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Disease in Patients With Obstructive Sleep Apnea Syndrome: A Multicenter Study
Background: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine th...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2018-01, Vol.24 (1), p.139-144 |
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| creator | Inonu Koseoglu, Handan Pazarli, Ahmet Cemal Kanbay, Asiye Demir, Osman |
| description | Background:
Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine the role of MHR in cardiovascular morbidity of patients with OSAS. We aimed to investigate the association between MHR and CVD in patients with OSAS and the relationship between severity of OSAS, polysomnographic parameters, and MHR.
Methods:
In this cohort study, patients who had undergone a full-night polysomnography for the diagnosis of OSAS were recruited. Included patients were grouped according to the apnea–hypopnea index (AHI) as mild (5-15), moderate (15-30), and severe (>30) OSAS. Patients with AHI < 5 served as the control group. The presence of heart failure, coronary artery disease, or arrhythmia was defined as CVD.
Results:
A total of 1050 patients were included (131 controls, 222 mild, 228 moderate, and 469 severe OSAS). The severe group had higher MHR compared with the control and other OSAS groups (9.99, 12.11, 13.65, and 20.67 in control, mild, moderate, and severe OSAS groups, respectively, P < .001). The MHRs were significantly correlated with AHI, oxygen desaturation index, and minimum O2 saturation values (P < .001). Values of MHR were significantly higher in patients with CVD compared with those without (P < .001). Multiple regression analysis demonstrated that MHR is an independent predictor of CVD.
Conclusion:
The MHR is strongly associated with CVD and the severity of OSAS and might be used as a biomarker to predict CVD in patients with OSAS. |
| doi_str_mv | 10.1177/1076029616677803 |
| format | Article |
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Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine the role of MHR in cardiovascular morbidity of patients with OSAS. We aimed to investigate the association between MHR and CVD in patients with OSAS and the relationship between severity of OSAS, polysomnographic parameters, and MHR.
Methods:
In this cohort study, patients who had undergone a full-night polysomnography for the diagnosis of OSAS were recruited. Included patients were grouped according to the apnea–hypopnea index (AHI) as mild (5-15), moderate (15-30), and severe (>30) OSAS. Patients with AHI < 5 served as the control group. The presence of heart failure, coronary artery disease, or arrhythmia was defined as CVD.
Results:
A total of 1050 patients were included (131 controls, 222 mild, 228 moderate, and 469 severe OSAS). The severe group had higher MHR compared with the control and other OSAS groups (9.99, 12.11, 13.65, and 20.67 in control, mild, moderate, and severe OSAS groups, respectively, P < .001). The MHRs were significantly correlated with AHI, oxygen desaturation index, and minimum O2 saturation values (P < .001). Values of MHR were significantly higher in patients with CVD compared with those without (P < .001). Multiple regression analysis demonstrated that MHR is an independent predictor of CVD.
Conclusion:
The MHR is strongly associated with CVD and the severity of OSAS and might be used as a biomarker to predict CVD in patients with OSAS.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029616677803</identifier><identifier>PMID: 27837155</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Biomarkers - blood ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cholesterol, HDL - blood ; Female ; Health risk assessment ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Monocytes ; Original ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - complications</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2018-01, Vol.24 (1), p.139-144</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>The Author(s) 2016 2016 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-244ac9d0d89fe6ee0cf19a336b82c3f26b730ee8f34b0af3bf0fe385724c52b43</citedby><cites>FETCH-LOGICAL-c462t-244ac9d0d89fe6ee0cf19a336b82c3f26b730ee8f34b0af3bf0fe385724c52b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714621/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714621/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,21946,27832,27903,27904,44924,45312,53769,53771</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029616677803?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27837155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inonu Koseoglu, Handan</creatorcontrib><creatorcontrib>Pazarli, Ahmet Cemal</creatorcontrib><creatorcontrib>Kanbay, Asiye</creatorcontrib><creatorcontrib>Demir, Osman</creatorcontrib><title>Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Disease in Patients With Obstructive Sleep Apnea Syndrome: A Multicenter Study</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Background:
Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine the role of MHR in cardiovascular morbidity of patients with OSAS. We aimed to investigate the association between MHR and CVD in patients with OSAS and the relationship between severity of OSAS, polysomnographic parameters, and MHR.
Methods:
In this cohort study, patients who had undergone a full-night polysomnography for the diagnosis of OSAS were recruited. Included patients were grouped according to the apnea–hypopnea index (AHI) as mild (5-15), moderate (15-30), and severe (>30) OSAS. Patients with AHI < 5 served as the control group. The presence of heart failure, coronary artery disease, or arrhythmia was defined as CVD.
Results:
A total of 1050 patients were included (131 controls, 222 mild, 228 moderate, and 469 severe OSAS). The severe group had higher MHR compared with the control and other OSAS groups (9.99, 12.11, 13.65, and 20.67 in control, mild, moderate, and severe OSAS groups, respectively, P < .001). The MHRs were significantly correlated with AHI, oxygen desaturation index, and minimum O2 saturation values (P < .001). Values of MHR were significantly higher in patients with CVD compared with those without (P < .001). Multiple regression analysis demonstrated that MHR is an independent predictor of CVD.
Conclusion:
The MHR is strongly associated with CVD and the severity of OSAS and might be used as a biomarker to predict CVD in patients with OSAS.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Original</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - complications</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kU9v1DAQxSNERUvhzglZ4sIlrf8kdswBaZXSFmmrIhbE0XKcSddV1t7azkr7Bfjc9WpLKZU4eaT3m-eZeUXxjuATQoQ4JVhwTCUnnAvRYPaiOCKSNSUVlL3MdZbLnX5YvI7xFmMiueSvikMqGiZIXR8Vv6-882abALV-cun08myO2qUfISYIfkTfdbIeadejVofe-o2OZhp1QGc2go6ArEPfMgMuRfTLpiW67mIKk0l2A2gxAqzRbO1Ao8XW9cGv4BOaoatpTNbkHghokaZ--6Y4GPQY4e3De1z8PP_yo70s59cXX9vZvDQVp6mkVaWN7HHfyAE4ADYDkZox3jXUsIHyTjAM0Ays6rAeWDfgAVhTC1qZmnYVOy4-733XU7eCfjdC0KNaB7vSYau8tupfxdmluvEbxQXJE5Bs8PHBIPi7KV9JrWw0MI7agZ-iIg2ThBJCZUY_PENv_RRcXk9RRvL9Ja5xpvCeMsHHGGB4HIZgtQtZPQ85t7x_usRjw59UM1Dugahv4O-v_zW8B9uNsQA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Inonu Koseoglu, Handan</creator><creator>Pazarli, Ahmet Cemal</creator><creator>Kanbay, Asiye</creator><creator>Demir, Osman</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Disease in Patients With Obstructive Sleep Apnea Syndrome: A Multicenter Study</title><author>Inonu Koseoglu, Handan ; Pazarli, Ahmet Cemal ; Kanbay, Asiye ; Demir, Osman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-244ac9d0d89fe6ee0cf19a336b82c3f26b730ee8f34b0af3bf0fe385724c52b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Original</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inonu Koseoglu, Handan</creatorcontrib><creatorcontrib>Pazarli, Ahmet Cemal</creatorcontrib><creatorcontrib>Kanbay, Asiye</creatorcontrib><creatorcontrib>Demir, Osman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Inonu Koseoglu, Handan</au><au>Pazarli, Ahmet Cemal</au><au>Kanbay, Asiye</au><au>Demir, Osman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Disease in Patients With Obstructive Sleep Apnea Syndrome: A Multicenter Study</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>24</volume><issue>1</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Background:
Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine the role of MHR in cardiovascular morbidity of patients with OSAS. We aimed to investigate the association between MHR and CVD in patients with OSAS and the relationship between severity of OSAS, polysomnographic parameters, and MHR.
Methods:
In this cohort study, patients who had undergone a full-night polysomnography for the diagnosis of OSAS were recruited. Included patients were grouped according to the apnea–hypopnea index (AHI) as mild (5-15), moderate (15-30), and severe (>30) OSAS. Patients with AHI < 5 served as the control group. The presence of heart failure, coronary artery disease, or arrhythmia was defined as CVD.
Results:
A total of 1050 patients were included (131 controls, 222 mild, 228 moderate, and 469 severe OSAS). The severe group had higher MHR compared with the control and other OSAS groups (9.99, 12.11, 13.65, and 20.67 in control, mild, moderate, and severe OSAS groups, respectively, P < .001). The MHRs were significantly correlated with AHI, oxygen desaturation index, and minimum O2 saturation values (P < .001). Values of MHR were significantly higher in patients with CVD compared with those without (P < .001). Multiple regression analysis demonstrated that MHR is an independent predictor of CVD.
Conclusion:
The MHR is strongly associated with CVD and the severity of OSAS and might be used as a biomarker to predict CVD in patients with OSAS.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27837155</pmid><doi>10.1177/1076029616677803</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and applied thrombosis/hemostasis, 2018-01, Vol.24 (1), p.139-144 |
| issn | 1076-0296 1938-2723 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Biomarkers - blood Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cholesterol, HDL - blood Female Health risk assessment Humans Leukocyte Count Male Middle Aged Monocytes Original Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications |
| title | Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Disease in Patients With Obstructive Sleep Apnea Syndrome: A Multicenter Study |
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