Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma
Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the importa...
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| Veröffentlicht in: | Journal of oral and maxillofacial pathology : JOMFP 2019-05, Vol.23 (2), p.307-307 |
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| description | Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain.
Aims and Objectives: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED).
Materials and Methods: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils.
Results: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann-Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC.
Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC. |
| doi_str_mv | 10.4103/jomfp.JOMFP_111_19 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6714271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A596938287</galeid><sourcerecordid>A596938287</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473h-8f646ea068d6fd58f17de289d92b4f13cb105a05a1ecacbdd7563e0487ddb1333</originalsourceid><addsrcrecordid>eNp9kl1rFDEUhoModq3-AS9kwOtZ8zEzmXghLLWtSqVeKPQuZPKxm-1MzjSZ6eK_N-22tQWRJATOed6XE94g9JbgZUUw-7CFwY3Lb-ffT35IQogk4hlaECHakgl28RwtsOCsxFRcHKBXKW0xrtuqpi_RASM1aWhNFqg7huQDjBvfp4_FKhR-GG1Uk7-2xcanCUY1baCHtdeqL8YI6wBp8rrwweTSBLFw-UDM3XQ1qwHmVGjb94VWUWfnQb1GL5zqk31zdx-iXyfHP4--lGfnp1-PVmelrjjblK1rqsYq3LSmcaZuHeHG0lYYQbvKEaY7gmuVN7Fa6c4YXjfM4qrlxnSEMXaIPu19x7kbrNE2THkqOUY_qPhbgvLyaSf4jVzDtWw4qSgn2eD9nUGEq9mmSW5hjiHPLCnlDadMtPwvtVa9lT44yGZ68EnLVS0awVp6Sy3_QeVl7OA1BOt8rj8R0L1AR0gpWvcwOMHyJm55G7d8HHcWvXv85AfJfb4Z-LwHdtBPNqbLft7ZKDN7GWD3H2vJMJf3f4P9AVQuwrE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2276723987</pqid></control><display><type>article</type><title>Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma</title><source>Medknow Open Access Medical Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Deepthi, G ; Kulkarni, Pavan ; K Nandan, S</creator><creatorcontrib>Deepthi, G ; Kulkarni, Pavan ; K Nandan, S</creatorcontrib><description>Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain.
Aims and Objectives: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED).
Materials and Methods: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils.
Results: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann-Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC.
Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC.</description><identifier>ISSN: 0973-029X</identifier><identifier>EISSN: 1998-393X</identifier><identifier>DOI: 10.4103/jomfp.JOMFP_111_19</identifier><identifier>PMID: 31516251</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Alcohol ; Archives & records ; Blood diseases ; Cancer ; Carcinogenesis ; Carcinoma ; Cytokines ; Cytotoxicity ; Development and progression ; Dysplasia ; Eosinophilia ; Fibroblasts ; Growth factors ; Inflammation ; Invasiveness ; Leukocytes (eosinophilic) ; Leukokeratosis ; Oral cancer ; Oral squamous cell carcinoma ; Original ; Pathogenesis ; Prognosis ; Squamous cell carcinoma ; Stains & staining ; Statistical analysis ; Studies ; Tobacco ; Tumors</subject><ispartof>Journal of oral and maxillofacial pathology : JOMFP, 2019-05, Vol.23 (2), p.307-307</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2019 Journal of Oral and Maxillofacial Pathology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473h-8f646ea068d6fd58f17de289d92b4f13cb105a05a1ecacbdd7563e0487ddb1333</citedby><cites>FETCH-LOGICAL-c473h-8f646ea068d6fd58f17de289d92b4f13cb105a05a1ecacbdd7563e0487ddb1333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714271/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714271/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27463,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31516251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deepthi, G</creatorcontrib><creatorcontrib>Kulkarni, Pavan</creatorcontrib><creatorcontrib>K Nandan, S</creatorcontrib><title>Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma</title><title>Journal of oral and maxillofacial pathology : JOMFP</title><addtitle>J Oral Maxillofac Pathol</addtitle><description>Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain.
Aims and Objectives: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED).
Materials and Methods: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils.
Results: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann-Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC.
Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC.</description><subject>Alcohol</subject><subject>Archives & records</subject><subject>Blood diseases</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinoma</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Development and progression</subject><subject>Dysplasia</subject><subject>Eosinophilia</subject><subject>Fibroblasts</subject><subject>Growth factors</subject><subject>Inflammation</subject><subject>Invasiveness</subject><subject>Leukocytes (eosinophilic)</subject><subject>Leukokeratosis</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Original</subject><subject>Pathogenesis</subject><subject>Prognosis</subject><subject>Squamous cell carcinoma</subject><subject>Stains & staining</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tobacco</subject><subject>Tumors</subject><issn>0973-029X</issn><issn>1998-393X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kl1rFDEUhoModq3-AS9kwOtZ8zEzmXghLLWtSqVeKPQuZPKxm-1MzjSZ6eK_N-22tQWRJATOed6XE94g9JbgZUUw-7CFwY3Lb-ffT35IQogk4hlaECHakgl28RwtsOCsxFRcHKBXKW0xrtuqpi_RASM1aWhNFqg7huQDjBvfp4_FKhR-GG1Uk7-2xcanCUY1baCHtdeqL8YI6wBp8rrwweTSBLFw-UDM3XQ1qwHmVGjb94VWUWfnQb1GL5zqk31zdx-iXyfHP4--lGfnp1-PVmelrjjblK1rqsYq3LSmcaZuHeHG0lYYQbvKEaY7gmuVN7Fa6c4YXjfM4qrlxnSEMXaIPu19x7kbrNE2THkqOUY_qPhbgvLyaSf4jVzDtWw4qSgn2eD9nUGEq9mmSW5hjiHPLCnlDadMtPwvtVa9lT44yGZ68EnLVS0awVp6Sy3_QeVl7OA1BOt8rj8R0L1AR0gpWvcwOMHyJm55G7d8HHcWvXv85AfJfb4Z-LwHdtBPNqbLft7ZKDN7GWD3H2vJMJf3f4P9AVQuwrE</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Deepthi, G</creator><creator>Kulkarni, Pavan</creator><creator>K Nandan, S</creator><general>Wolters Kluwer India Pvt. 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S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473h-8f646ea068d6fd58f17de289d92b4f13cb105a05a1ecacbdd7563e0487ddb1333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Archives & records</topic><topic>Blood diseases</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinoma</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Development and progression</topic><topic>Dysplasia</topic><topic>Eosinophilia</topic><topic>Fibroblasts</topic><topic>Growth factors</topic><topic>Inflammation</topic><topic>Invasiveness</topic><topic>Leukocytes (eosinophilic)</topic><topic>Leukokeratosis</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Original</topic><topic>Pathogenesis</topic><topic>Prognosis</topic><topic>Squamous cell carcinoma</topic><topic>Stains & staining</topic><topic>Statistical 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Pathol</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>23</volume><issue>2</issue><spage>307</spage><epage>307</epage><pages>307-307</pages><issn>0973-029X</issn><eissn>1998-393X</eissn><abstract>Background: Inflammation in tumor microenvironment assists in both promotion and growth of tumor. Tumor-associated tissue eosinophilia (TATE) is the term used when eosinophils are observed in a tumor tissue with inflammatory infiltrate. Although carcinogenesis with inflammation is one of the important hallmarks, the exact role of eosinophils remains unclear. Various studies on oral squamous cell carcinoma (OSCC) that focused on eosinophils reported both favorable and unfavorable prognosis in cancer tissue, because of which the exact function of eosinophils still remains uncertain.
Aims and Objectives: The present study aims at identifying the role of TATE in OSCC and in malignant transformation of oral epithelial dysplasia (OED).
Materials and Methods: The study includes 70 samples that divided into two groups, of which 50 histopathologically proven cases of different grades of OSCC and 20 cases of OED (oral leukoplakia). Congo red stain was used to stain the tissue sections. Each slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils.
Results: Statistical analysis of values obtained was done using ANOVA, unpaired t-test and Mann-Whitney test. The results were statistically significant (P < 0.05) with a mean total eosinophil count of 2.12 in OED and 4.31 in OSCC.
Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>31516251</pmid><doi>10.4103/jomfp.JOMFP_111_19</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Archives & records Blood diseases Cancer Carcinogenesis Carcinoma Cytokines Cytotoxicity Development and progression Dysplasia Eosinophilia Fibroblasts Growth factors Inflammation Invasiveness Leukocytes (eosinophilic) Leukokeratosis Oral cancer Oral squamous cell carcinoma Original Pathogenesis Prognosis Squamous cell carcinoma Stains & staining Statistical analysis Studies Tobacco Tumors |
| title | Eosinophils: An imperative histopathological prognostic indicator for oral squamous cell carcinoma |
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